MARCH10 antibody (Cy5)

Catalog No. ABIN1419558

The Cy5-conjugated Rabbit Polyclonal anti-MARCH10 antibody (ABIN1419558) specifically detects MARCH10 in WB and IF (p). The antibody is reactive with Human, Rat and Mouse samples.

Quick Overview for MARCH10 antibody (Cy5) (ABIN1419558)

Target: MARCH10 (Membrane-Associated Ring Finger (C3HC4) 10, E3 Ubiquitin Protein Ligase (MARCH10))

Reactivity: Human, Rat, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This MARCH10 antibody is conjugated to Cy5

Application: Western Blotting (WB), Immunofluorescence (Paraffin-embedded Sections) (IF (p))

Product Details anti-MARCH10 Antibody (Cy5)

Cross-Reactivity: Human, Mouse, Rat

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human RNF190

Isotype: IgG

Application Details

Application Notes: IF(IHC-P) 1:50-200

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Expiry Date: 12 months

Target Details for MARCH10

Target: MARCH10 (Membrane-Associated Ring Finger (C3HC4) 10, E3 Ubiquitin Protein Ligase (MARCH10))

Alternative Name: RNF190

Background:

Synonyms: MARCH 10, MARCH X, MARCH-X, MARCH10, MARHA_HUMAN, Membrane associated ring finger C3HC4 10, Membrane associated ring finger C3HC4 10, E3 ubiquitin protein ligase, Membrane associated ring finger 10, Membrane associated RING finger protein 10, Membrane-associated RING finger protein 10, Membrane-associated RING-CH protein X, Probable E3 ubiquitin protein ligase MARCH10, Probable E3 ubiquitin-protein ligase MARCH10, Ring finger protein 190, RNF 190, RNF190.

Background: The RING-type zinc finger motif is present in a number of viral and eukaryotic proteins and is made of a conserved cysteine-rich domain that is able to bind two zinc atoms. Proteins that contain this conserved domain are generally involved in the ubiquitination pathway of protein degradation. MARCH10 (membrane-associated ring finger (C3HC4) 10), also known as RNF190 (ring finger protein 190) or MARCH-X, is an 808 amino acid protein with one RING-CH-type zinc finger domain. MARCH10 may function as an E3 ubiquitin-protein ligase that accepts a ubiquitin residue from an E2 ubiquitin-conjugating enzyme and immediately transfers that residue to a protein that is targeted for degradation.

Gene ID: 162333