Serotonin Receptor 2B antibody (PE-Cy7)

Catalog No. ABIN1429484

The Rabbit Polyclonal anti-Serotonin Receptor 2B antibody has been validated for WB. It is suitable to detect Serotonin Receptor 2B in samples from Human.

Quick Overview for Serotonin Receptor 2B antibody (PE-Cy7) (ABIN1429484)

Target: Serotonin Receptor 2B (HTR2B)

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Serotonin Receptor 2B antibody is conjugated to PE-Cy7

Application: Western Blotting (WB)

Product Details anti-Serotonin Receptor 2B Antibody (PE-Cy7)

Cross-Reactivity: Human

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human 5HT2B Receptor/SR-2B

Isotype: IgG

Application Details

Application Notes: WB: 1:300-5000
Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Expiry Date: 12 months

Target Details for Serotonin Receptor 2B

Target: Serotonin Receptor 2B (HTR2B)

Background:

Synonyms: 5 HT 2B, 5 HT 2B receptor, 5 HT2B, 5 HT2B, 5 hydroxytryptamine serotonin receptor 2B, 5 hydroxytryptamine serotonin receptor 2B G protein coupled, 5 hydroxytryptamine 2B receptor, 5 hydroxytryptamine receptor 2B, 5-HT-2B, 5-HT2B, 5-hydroxytryptamine receptor 2B, 5HT2B, 5HT2B_HUMAN, 5HT2F, Htr 2b, Htr2b, NP75 protein, SEROTONIN 5HT2B RECEPTOR, Serotonin receptor 2B, Stomach fundus serotonin receptor.

Background: Serotonin (also designated 5-hydroxytryptamine or 5-HT) is a molecule that functions as a neurotransmitter, a hormone and a mitogen, and it is predominantly expressed in the gut, platelets and central nervous system (CNS). In the CNS, serotonin modulates several processes, including anxiety, sleep, appetite, behavior and drug abuse. In platelets and gut, serotonin plays a major role in cardiovascular function and motility of the gastrointestinal tract, respectively. Serotonin mediates its effects through several of G protein coupled receptors, designated 5-HT receptors or alternatively SR receptors. The SR-2 receptors are comprised of three subtypes, SR-2A, SR-2B and SR-2C, which activate phospholipase C and release intracellular stores of calcium in response to serotonin. SR-2A has a specific role in tracheal smooth muscle contraction, bronchoconstriction and mediating aldosterone production, and it is also thought to play a role in several psychiatric disorders, including depression and schizophrenia. SR-2B is expressed in embryonic and adult cardiovascular tissues, gut and brain and plays an important role in the pathology of cardiac disorders. SR-2C is thought to mediate the effects of atypical antipsychotic drugs.

Molecular Weight: 54kDa

Pathways: JAK-STAT Signaling, Inositol Metabolic Process, Regulation of G-Protein Coupled Receptor Protein Signaling, Regulation of Carbohydrate Metabolic Process