ATR antibody

Catalog No. ABIN1449281

The Mouse Monoclonal anti-ATR antibody has been validated for WB. It is suitable to detect ATR in samples from Human.

Quick Overview for ATR antibody (ABIN1449281)

Target: ATR (Ataxia Telangiectasia and Rad3 Related (ATR))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This ATR antibody is un-conjugated

Application: Western Blotting (WB)

Clone: 4D7

Product Details anti-ATR Antibody

Sequence: CPCELEHSIK PLFQHSPGDS SQED

Specificity: This antibody reacts with human ATR.

Purification: Protein A agarose

Immunogen: Carrier protein (CP) conjugated synthetic peptide

Isotype: IgG1

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Concentration: 1.0 mg/mL

Buffer: PBS containing 50 % glycerol, pH 7.2. Contains no preservatives.

Preservative: Without preservative

Handling Advice: Avoid repeated freezing and thawing.

Storage: -20 °C

Storage Comment: Upon receipt, store (in aliqouts) at -20 °C.

Target Details for ATR

Target: ATR (Ataxia Telangiectasia and Rad3 Related (ATR))

Alternative Name: ATR / FRP1

Background: ATR (ataxia telangiectasia and Rad-3-related) is one of the most important checkpoint proteins in mammalian cells responding to DNA damage. ATR is a member of the phosphatidylinositol kinase-related protein family that includes ATM (ataxia telangiectasia mutated). These kinases are essential for signaling the presence of DNA damage or replication blocks and activating cell cycle checkpoints. It is reported that checkpoint kinase 1 (CHK1), RAD9, RAD17, Histone H2AX, p53, and BRCA1 are phosphorylated in response to genotoxic stress in an ATR-dependent manner. ATR also phosphorylates ATR-interacting protein (ATRIP) that regulates ATR expression, and is an essential component of the DNA damage checkpoint signaling pathways. In addition, homozygous deletion of ATR in mice causes early embryonic lethality, suggesting that ATR has essential functions during development.Synonyms: Ataxia telangiectasia and Rad3-related protein, FRAP-related protein 1, Serine/threonine-protein kinase ATR

Gene ID: 545

NCBI Accession: NP_001175

UniProt: Q13535

Pathways: p53 Signaling, Apoptosis, DNA Damage Repair, Positive Regulation of Response to DNA Damage Stimulus