CDCA8 antibody (N-Term)

Catalog No. ABIN1449290

The Mouse Monoclonal anti-CDCA8 antibody is suitable to detect CDCA8 in samples from Human. It has been validated for WB, IF and IP.

Quick Overview for CDCA8 antibody (N-Term) (ABIN1449290)

Target: CDCA8 (Cell Division Cycle Associated 8 (CDCA8))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This CDCA8 antibody is un-conjugated

Application: Western Blotting (WB), Immunofluorescence (IF), Immunoprecipitation (IP)

Clone: 1D11

Product Details anti-CDCA8 Antibody

Binding Specificity: AA 1-280, N-Term

Specificity: This antibody reacts with Borealin (35 kDa).

Cross-Reactivity (Details): Species reactivity (tested):Human

Purification: Protein A agarose

Immunogen: Recombinant full-length human Borealin (1-280 aa)

Isotype: IgG2a

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Concentration: 1.0 mg/mL

Buffer: PBS containing 50 % glycerol, pH 7.2. No preservative is contained.

Preservative: Without preservative

Handling Advice: Avoid repeated freezing and thawing.

Storage: -20 °C

Storage Comment: Upon receipt, store (in aliqouts) at -20 °C.

Target Details for CDCA8

Target: CDCA8 (Cell Division Cycle Associated 8 (CDCA8))

Alternative Name: CDCA8 / Borealin

Background: Borealin is a subunit of the chromosomal passenger complex (CPC), which is necessary for chromosome segregation and cytokinesis. While CPC shows a dynamic localization pattern during mitosis, Borealin and survivin, another subunit of CPC is essential to localize CPC at centromare from prophase to anaphase. It is thought that Borealin and survivin recruit aurora B, a kinase subunit of CPC, to inner centromare to allow phosphorylating appropriate substrates.Synonyms: Cell division cycle-associated protein 8, Dasra-B, PESCRG3, Pluripotent embryonic stem cell-related gene 3 protein, hDasra-B

Gene ID: 55143

NCBI Accession: NP_060571

UniProt: Q53HL2

Pathways: Cell Division Cycle, M Phase