ALAS2 antibody (C-Term)

Catalog No. ABIN1449876

The Rabbit Polyclonal anti-ALAS2 antibody (ABIN1449876) specifically detects ALAS2 in WB. The antibody is reactive with Human, Mouse, Rat, Cow, Zebrafish (Danio rerio) and Xenopus laevis samples.

Quick Overview for ALAS2 antibody (C-Term) (ABIN1449876)

Target: ALAS2 (Aminolevulinate, delta-, Synthase 2 (ALAS2))

Reactivity: Human, Mouse, Rat, Cow, Zebrafish (Danio rerio), Xenopus laevis

Host: Rabbit

Clonality: Polyclonal

Conjugate: This ALAS2 antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-ALAS2 Antibody

Binding Specificity: C-Term

Sequence: VRLLKGEEGQ ALRRAHQRNV KHMRQLLMDR GLPVIPCPSH IIPIRVGNAA

Cross-Reactivity (Details): Species reactivity (expected):Mouse, Rat, Bovine, African clawed frog, ZebrafishSpecies reactivity (tested):Human

Purification: Purified using peptide immunoaffinity column

Immunogen: Synthetic peptide directed towards the C terminal of human ALAS2

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Reconstitution: Add 50 μL of distilled water to a final concentration of 1 mg/mL.

Handling Advice: Avoid repeated freezing and thawing.

Storage: 4 °C/-20 °C

Storage Comment: Store lyophilized at 2-8 °C or at -20 °C long term. After reconstitution store the antibody undiluted at 2-8 °C for up to one month or in aliquots at -20 °C long term.

Target Details for ALAS2

Target: ALAS2 (Aminolevulinate, delta-, Synthase 2 (ALAS2))

Alternative Name: ALAS2

Background: ALAS2 specifies an erythroid-specific mitochondrially located enzyme. It catalyzes the first step in the heme biosynthetic pathway. Defects in this gene cause X-linked pyridoxine-responsive sideroblastic anemia.The product of this gene specifies an erythroid-specific mitochondrially located enzyme. The encoded protein catalyzes the first step in the heme biosynthetic pathway. Defects in this gene cause X-linked pyridoxine-responsive sideroblastic anemia. Alternatively spliced transcript variants encoding different isoforms have been identified.Synonyms: 5-aminolevulinate synthase erythroid-specific mitochondrial, 5-aminolevulinic acid synthase, ALASE, ASB, Delta-ALA synthetase, Delta-aminolevulinate synthase

Gene ID: 212

NCBI Accession: NP_000023

Pathways: Transition Metal Ion Homeostasis