ALG8 antibody

Catalog No. ABIN1449889

This Rabbit Polyclonal antibody specifically detects ALG8 in WB. It exhibits reactivity toward Human, Mouse, Cow, Dog, Pig, Rat and Chicken.

Quick Overview for ALG8 antibody (ABIN1449889)

Target: ALG8 (Asparagine-Linked Glycosylation 8, alpha-1,3-Glucosyltransferase Homolog (ALG8))

Reactivity: Human, Mouse, Cow, Dog, Pig, Rat, Chicken

Host: Rabbit

Clonality: Polyclonal

Conjugate: This ALG8 antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-ALG8 Antibody

Sequence: LELKLLDPSQ IPRASMTSGL VQQSQHTVLP SVSPSATLIC TLIAILPSVF

Cross-Reactivity (Details): Species reactivity (expected):Mouse, Human, Chicken, Dog, Bovine, PigSpecies reactivity (tested):Human

Purification: Purified using peptide immunoaffinity column

Immunogen: Synthetic peptide corresponding to a region of Rat ALG8

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Reconstitution: Add 50 μL of distilled water to a final concentration of 1 mg/mL.

Handling Advice: Avoid repeated freezing and thawing.

Storage: 4 °C/-20 °C

Storage Comment: Store lyophilized at 2-8 °C or at -20 °C long term. After reconstitution store the antibody undiluted at 2-8 °C for up to one month or in aliquots at -20 °C long term.

Target Details for ALG8

Target: ALG8 (Asparagine-Linked Glycosylation 8, alpha-1,3-Glucosyltransferase Homolog (ALG8))

Alternative Name: ALG8

Background: ALG8 adds the second glucose residue to the lipid-linked oligosaccharide precursor for N-linked glycosylation and transfers glucose from dolichyl phosphate glucose (Dol-P-Glc) onto the lipid-linked oligosaccharide Glc1Man9GlcNAc(2)-PP-Dol. Defects in ALG8 are the cause of congenital disorder of glycosylation type 1H (CDG1H). CDGs are a family of severe inherited diseases caused by a defect in protein N-glycosylation. They are characterized by under-glycosylated serum proteins. These multisystem disorders present with a wide variety of clinical features, such as disorders of the nervous system development, psychomotor retardation, dysmorphic features, hypotonia, coagulation disorders, and immunodeficiency. The broad spectrum of features reflects the critical role of N-glycoproteins during embryonic development, differentiation, and maintenance of cell functions.Synonyms: 3-glucosyltransferase, Asparagine-linked glycosylation protein 8, Dolichyl-P-Glc:Glc1Man9GlcNAc2-PP-dolichyl glucosyltransferase, HUSSY-02, Probable dolichyl pyrophosphate Glc1Man9GlcNAc2 alpha-1

Gene ID: 293129

NCBI Accession: NP_001029299

Pathways: SARS-CoV-2 Protein Interactome