WDR35 antibody (N-Term)

Catalog No. ABIN1449959

Product Details anti-WDR35 Antibody

Target: WDR35 (WD Repeat Domain 35 (WDR35))

Binding Specificity: N-Term

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This WDR35 antibody is un-conjugated

Application: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Enzyme Immunoassay (EIA)

Purification: Affinity chromatography purified via peptide column

Immunogen: 16 amino acid synthetic peptide near the amino terminus of Human WDR35

Isotype: IgG

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Concentration: 1.0 mg/mL

Buffer: PBS containing 0.02 % Sodium Azide as preservative

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freezing and thawing.

Storage: 4 °C/-20 °C

Storage Comment: Store undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Target Details for WDR35

Target: WDR35 (WD Repeat Domain 35 (WDR35))

Alternative Name: WDR35 (WDR35 Products)

Synonyms: 4930459M12Rik antibody, 4931430C06 antibody, mKIAA1336 antibody, RGD1564116 antibody, Wdr35 antibody, CED2 antibody, IFT121 antibody, im:7159945 antibody, si:ch211-206k20.4 antibody, WD repeat domain 35 antibody, Wdr35 antibody, WDR35 antibody, wdr35 antibody

Background: WD40 repeats are a common structural module in eukaryotic proteins, and proteins containing WD40 domains have a wide range of functions, including signal transduction, cell cycle regulation, RNA splicing, and transcription. One such protein, WDR35, also known as CED2, has been shown to be mutated in patients with Sensenbrenner syndrome/cranioectodermal dysplasia (CED), an autosomal-recessive disease that is characterized by craniosynstosis and ectodermal and skeletal abnormalities. WDR35 localizes to cilia and dentrosomes during embryogenesis and human and mouse fibroblasts that lack this gene fail to produce cilia. Mutations in this gene can also cause short-rib polydactyly syndromes due to abnormal ciliogenesis.Synonyms: IFT121, Intraflagellar transport protein 121 homolog, KIAA1336, WD repeat-containing protein 35

Gene ID: 57539

NCBI Accession: NP_001006658

Pathways: Hedgehog Signaling