TTBK2 antibody (C-Term)

Catalog No. ABIN1449960

This anti-TTBK2 antibody is a Rabbit Polyclonal antibody detecting TTBK2 in IHC (p) and EIA. Suitable for Human.

Quick Overview for TTBK2 antibody (C-Term) (ABIN1449960)

Target: TTBK2 (tau Tubulin Kinase 2 (TTBK2))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This TTBK2 antibody is un-conjugated

Application: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Enzyme Immunoassay (EIA)

Product Details anti-TTBK2 Antibody

Binding Specificity: C-Term

Purification: Affinity chromatography purified via peptide column

Immunogen: 18 amino acid synthetic peptide near the carboxy terminus of Human TTBK2

Isotype: IgG

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Concentration: 1.0 mg/mL

Buffer: PBS containing 0.02 % Sodium Azide as preservative

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freezing and thawing.

Storage: 4 °C/-20 °C

Storage Comment: Store undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Target Details for TTBK2

Target: TTBK2 (tau Tubulin Kinase 2 (TTBK2))

Alternative Name: TTBK2

Background: Tau tubulin kinase (TTBK2) is a serine/threonine kinase whose substrates are thought to include the tau and tubulin proteins. Mutations in the TTBK2 gene cause spinocerebellar ataxia type 11 (SCA11), a neurodegenerative disease characterized by progressive ataxia and atrophy of the cerebellum and brainstem. Recent studies have shown that increased levels of TTBK2 expression in kidney carcinoma and melanoma cell lines increases resistance to the chemotherapeutic agent Sunitinib, and that reduction of TTBK2 though the use of siRNA sensitized these cell lines to the effects of Sunitib, suggesting that TTBK2 can be used as a resistance marker as well a potential target to overcome resistance.Synonyms: KIAA0847, Tau-tubulin kinase 2

Gene ID: 146057