TTBK2 antibody (C-Term)

Catalog No. ABIN6258666

Product Details anti-TTBK2 Antibody

Target: TTBK2 (tau Tubulin Kinase 2 (TTBK2))

Binding Specificity: C-Term

Reactivity: Human, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This TTBK2 antibody is un-conjugated

Application: Western Blotting (WB), ELISA

Specificity: TTBK2 Antibody detects endogenous levels of total TTBK2.

Predicted Reactivity: Pig,Bovine,Horse,Sheep,Rabbit,Dog,Xenopus

Purification: The antiserum was purified by peptide affinity chromatography using SulfoLink^TM Coupling Resin (Thermo Fisher Scientific).

Immunogen: A synthesized peptide derived from human TTBK2, corresponding to a region within C-terminal amino acids.

Isotype: IgG

Application Details

Application Notes: WB 1:500-1:2000, ELISA(peptide) 1:20000-1:40000

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: Rabbit IgG in phosphate buffered saline, pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Expiry Date: 12 months

Target Details for TTBK2

Target: TTBK2 (tau Tubulin Kinase 2 (TTBK2))

Alternative Name: TTBK2 (TTBK2 Products)

Synonyms: ttbk antibody, MGC146331 antibody, 2610507N02Rik antibody, AI326283 antibody, B930008N24Rik antibody, TTK antibody, Ttbk antibody, Ttbk1 antibody, mKIAA0847 antibody, SCA11 antibody, TTBK antibody, tau tubulin kinase 2 antibody, TTBK2 antibody, ttbk2 antibody, Ttbk2 antibody

Background:

Description: Serine/threonine kinase that acts as a key regulator of ciliogenesis: controls the initiation of ciliogenesis by binding to the distal end of the basal body and promoting the removal of CCP110, which caps the mother centriole, leading to the recruitment of IFT proteins, which build the ciliary axoneme. Has some substrate preference for proteins that are already phosphorylated on a Tyr residue at the +2 position relative to the phosphorylation site. Able to phosphorylate tau on serines in vitro.

Gene: TTBK2

Molecular Weight: 137 kDa

Gene ID: 146057

UniProt: Q6IQ55