DRAXIN antibody (C-Term)

Catalog No. ABIN6991584

Product Details anti-DRAXIN Antibody

Target: DRAXIN (Dorsal Inhibitory Axon Guidance Protein (DRAXIN))

Binding Specificity: C-Term

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This DRAXIN antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunofluorescence (IF)

Specificity: At least three isoforms of Neucrin are known to exist, this antibody will detect the two shorter isoforms. Neucrin antibody is predicted to not cross-react with RILP.

Purification: NEUCRIN Antibody is affinity chromatography purified via peptide column.

Immunogen: Neucrin antibody was raised against a 17 amino acid synthetic peptide near the carboxy terminus of human Neucrin. The immunogen is located within the last 50 amino acids of NEUCRIN.

Isotype: IgG

Application Details

Application Notes: Neucrin antibody can be used for detection of Neucrin by Western blot at 1 μ,g/mL. Antibody can also be used for immunohistochemistry starting at 5 μ,g/mL. For immunofluorescence start at 20 μ,g/mL.

Antibody validated: Western Blot in rat samples, Immunohistochemistry in mouse samples and Immunofluorescence in mouse samples. All other applications and species not yet tested.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: NEUCRIN Antibody is supplied in PBS containing 0.02 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,4 °C

Storage Comment: NEUCRIN antibody can be stored at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Target Details for DRAXIN

Target: DRAXIN (Dorsal Inhibitory Axon Guidance Protein (DRAXIN))

Alternative Name: NEUCRIN (DRAXIN Products)

Synonyms: C1orf187 antibody, draxin antibody, AGPA3119 antibody, UNQ3119 antibody, neucrin antibody, 2610109H07Rik antibody, MGC113312 antibody, dorsal inhibitory axon guidance protein antibody, DRAXIN antibody, Draxin antibody, draxin antibody

Background: NEUCRIN Antibody: Neucrin, also known as Draxin, is a repulsive guidance protein for the spinal cord and forebrain commissures. It is thought to act as an antagonist of canonical Wnt signaling by inhibiting the stabilization of cytosolic beta-catenin. Ectopically expressed neucrin inhibited growth or caused misrouting of chick spinal cord commissural axons in vivo while Neucrin-null mice showed defasciculation of spinal cord commissural axons and an absence of all forebrain commisures. Other experiments in mice have shown that olfactory bulb axonal outgrowth is inhibited by Neucrin, suggesting that Neucrin functions as an inhibitory guidance cue for olfactory bulb axons.

Gene ID: 374946

UniProt: Q8NBI3