RAPGEF4 antibody (N-Term)

Catalog No. ABIN1450105

This Rabbit Polyclonal antibody specifically detects RAPGEF4 in WB and IHC (p). It exhibits reactivity toward Human, Mouse and Rat.

Quick Overview for RAPGEF4 antibody (N-Term) (ABIN1450105)

Target: RAPGEF4 (Rap Guanine Nucleotide Exchange Factor (GEF) 4 (RAPGEF4))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This RAPGEF4 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Product Details anti-RAPGEF4 Antibody

Binding Specificity: N-Term

Cross-Reactivity (Details): Species reactivity (tested):Human, Mouse, Rat

Purification: Affinity chromatography purified via peptide column

Immunogen: 15 amino acid synthetic peptide near the amino terminus of human RAPGEF4 / EPAC2

Isotype: IgG

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Concentration: 1.0 mg/mL

Buffer: PBS containing 0.02 % Sodium Azide as preservative

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freezing and thawing.

Storage: 4 °C/-20 °C

Storage Comment: Store undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Target Details for RAPGEF4

Target: RAPGEF4 (Rap Guanine Nucleotide Exchange Factor (GEF) 4 (RAPGEF4))

Alternative Name: RAPGEF4

Background: EPAC2, also known as Rap guanine nuclear exchange factor 4 (RAPGEF4) and cAMPGEF-II, is belongs to a family of cyclic adenosine monophosphate (cAMP) binding proteins with guanine nucleotide exchange factor. Like the related protein EPAC1, EPAC2 signaling plays a role in numerous cellular processes such as integrin-mediated cell adhesion, muscle contraction, learning and memory, cell proliferation, and inflammation. Recent evidence suggests that EPAC2 induces synapse remodeling and depression, with mutations in its gene being found in patients with autism.Synonyms: CGEF2, EPAC 2, EPAC2, Exchange factor directly activated by cAMP 2, Exchange protein directly activated by cAMP 2, Rap guanine nucleotide exchange factor 4, cAMP-GEFII, cAMP-regulated guanine nucleotide exchange factor II

Gene ID: 11069

NCBI Accession: NP_008954

Pathways: Hormone Transport, Smooth Muscle Cell Migration