FOXRED2 antibody (N-Term)

Catalog No. ABIN1450133

The Rabbit Polyclonal anti-FOXRED2 antibody is suitable to detect FOXRED2 in samples from Human. It has been validated for WB, IF and EIA.

Quick Overview for FOXRED2 antibody (N-Term) (ABIN1450133)

Target: FOXRED2 (FAD-Dependent Oxidoreductase Domain Containing 2 (FOXRED2))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This FOXRED2 antibody is un-conjugated

Application: Western Blotting (WB), Immunofluorescence (IF), Enzyme Immunoassay (EIA)

Product Details anti-FOXRED2 Antibody

Binding Specificity: N-Term

Cross-Reactivity (Details): Species reactivity (tested):Human.

Purification: Affinity chromatography purified via peptide column

Immunogen: 17 amino acid synthetic peptide near the amino terminus of Human FOXRED2

Isotype: IgG

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Concentration: 1.0 mg/mL

Buffer: PBS containing 0.02 % Sodium Azide as preservative

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freezing and thawing.

Storage: 4 °C/-20 °C

Storage Comment: Store undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Target Details for FOXRED2

Target: FOXRED2 (FAD-Dependent Oxidoreductase Domain Containing 2 (FOXRED2))

Alternative Name: FOXRED2

Background: FOXRED2, also known as ERFAD, is an endoplasmic reticulum (ER) luminal flavoprotein which may function in ER associated degradation (ERAD). It has been proposed to bind non-native proteins in the endoplasmic reticulum and target them to the ubiquitination machinery for subsequent degradation. Upon knockdown of FOXRED2, the degradation of the ERAD model substrate ribophorin 332 is delayed, and the overall level of polyubiquitinated cellular proteins is decreased. Defects in the related protein FOXRED1 are a cause of mitochondrial complex I deficiency (MT-C1D), suggesting the FOXRED2 may also play a role in MT-C1D.Synonyms: FAD-dependent oxidoreductase domain-containing protein 2

Gene ID: 80020

Pathways: SARS-CoV-2 Protein Interactome