LKB1 antibody (pSer334)

Catalog No. ABIN1450431

The Rabbit Polyclonal anti-LKB1 antibody (ABIN1450431) specifically detects LKB1 in IHC, ELISA and IF. The antibody is reactive with Human and Mouse samples.

Quick Overview for LKB1 antibody (pSer334) (ABIN1450431)

Target: LKB1 (STK11) (serine/threonine Kinase 11 (STK11))

Reactivity: Human, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This LKB1 antibody is un-conjugated

Application: Immunohistochemistry (IHC), ELISA, Immunofluorescence (IF)

Product Details anti-LKB1 Antibody

Binding Specificity: AA 300-349, pSer334

Purpose: LKB1 (phospho Ser334) Antibody

Specificity: Phospho-LKB1 (S334) Polyclonal Antibody detects endogenous levels of LKB1 protein only when phosphorylated at S334.

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Immunogen: The antiserum was produced against synthesized peptide derived from human LKB1 around the phosphorylation site of Ser334. AA range:300-349

Isotype: IgG

Application Details

Application Notes: IHC 1:100 - 1:300. ELISA: 1:10000.. IF 1:50-200

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: Liquid in PBS containing 50 % glycerol, 0.5 % BSA and 0.02 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C/1 year

Expiry Date: 12 months

Target Details for LKB1

Target: LKB1 (STK11) (serine/threonine Kinase 11 (STK11))

Alternative Name: LKB1

Background:

Synonyms: STK11, LKB1, PJS, Serine/threonine-protein kinase STK11, Liver kinase B1, LKB1, hLKB1, Renal carcinoma antigen NY-REN-19

Background: This gene, which encodes a member of the serine/threonine kinase family, regulates cell polarity and functions as a tumor suppressor. Mutations in this gene have been associated with Peutz-Jeghers syndrome, an autosomal dominant disorder characterized by the growth of polyps in the gastrointestinal tract, pigmented macules on the skin and mouth, and other neoplasms. Alternate transcriptional splice variants of this gene have been observed but have not been thoroughly characterized. [provided by RefSeq, Jul 2008],

Gene Name: STK11

Protein Name: Serine/threonine-protein kinase STK11

Molecular Weight: 48 kDa

Gene ID: 6794

OMIM: 175200

UniProt: Q15831

Pathways: AMPK Signaling, Carbohydrate Homeostasis, Regulation of Carbohydrate Metabolic Process, Warburg Effect