SIN3B antibody (AA 221-270)

Catalog No. ABIN1450803

The Rabbit Polyclonal anti-SIN3B antibody (ABIN1450803) specifically detects SIN3B in WB, ELISA and IHC. The antibody is reactive with Human, Mouse and Rat samples.

Quick Overview for SIN3B antibody (AA 221-270) (ABIN1450803)

Target: SIN3B (SIN3 Transcription Regulator Homolog B (SIN3B))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This SIN3B antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunohistochemistry (IHC)

Product Details anti-SIN3B Antibody

Binding Specificity: AA 221-270

Purpose: Sin3B Antibody

Specificity: Sin3B Polyclonal Antibody detects endogenous levels of Sin3B protein.

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Immunogen: The antiserum was produced against synthesized peptide derived from human SIN3B. AA range:221-270

Isotype: IgG

Application Details

Application Notes: WB 1:500-2000,IHC 1:50-300, ELISA 2000-20000

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: Liquid in PBS containing 50 % glycerol, 0.5 % BSA and 0.02 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C/1 year

Expiry Date: 12 months

Target Details for SIN3B

Target: SIN3B (SIN3 Transcription Regulator Homolog B (SIN3B))

Alternative Name: SIN3B

Background:

Synonyms: SIN3B, KIAA0700, Paired amphipathic helix protein Sin3b, Histone deacetylase complex subunit Sin3b, Transcriptional corepressor Sin3b

Background: function:Acts as a transcriptional repressor. Interacts with MXI1 to repress MYC responsive genes and antagonize MYC oncogenic activities. Interacts with MAD-MAX heterodimers by binding to MAD. The heterodimer then represses transcription by tethering SIN3B to DNA. Also forms a complex with FOXK1 which represses transcription.,similarity:Contains 3 PAH (paired amphipathic helix) repeats.,subunit:Interacts with FOXK1/MNF, MXI, MAD, NCOR1 and SAP30. Interaction with SDS3 enhances the interaction with HDAC1 to form a complex. Interacts with MAD3, MAD4, MAEL, REST and SETDB1 (By similarity). Interacts with HCFC1.,

Gene Name: SIN3B

Protein Name: Paired amphipathic helix protein Sin3b

Molecular Weight: 133 kDa

Gene ID: 23309

OMIM: 607777

UniProt: O75182