RNF111 antibody (AA 901-950)

Catalog No. ABIN1451235

The Rabbit Polyclonal anti-RNF111 antibody (ABIN1451235) specifically detects RNF111 in WB and ELISA. The antibody is reactive with Human and Mouse samples.

Quick Overview for RNF111 antibody (AA 901-950) (ABIN1451235)

Target: RNF111 (Ring Finger Protein 111 (RNF111))

Reactivity: Human, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This RNF111 antibody is un-conjugated

Application: Western Blotting (WB), ELISA

Product Details anti-RNF111 Antibody

Binding Specificity: AA 901-950

Purpose: Arkadia Antibody

Specificity: Arkadia Polyclonal Antibody detects endogenous levels of Arkadia protein.

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Immunogen: The antiserum was produced against synthesized peptide derived from human RNF111. AA range:901-950

Isotype: IgG

Application Details

Application Notes: WB 1:500 - 1:2000. ELISA: 1:40000. Not yet tested in other applications.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: Liquid in PBS containing 50 % glycerol, 0.5 % BSA and 0.02 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C/1 year

Expiry Date: 12 months

Target Details for RNF111

Target: RNF111 (Ring Finger Protein 111 (RNF111))

Alternative Name: RNF111

Background:

Synonyms: RNF111, E3 ubiquitin-protein ligase Arkadia, RING finger protein 111

Background: ring finger protein 111(RNF111) Homo sapiens The protein encoded by this gene is a nuclear RING-domain containing E3 ubiquitin ligase. This protein interacts with the transforming growth factor (TGF) -beta/NODAL signaling pathway by promoting the ubiquitination and proteosomal degradation of negative regulators, like SMAD proteins, and thereby enhances TGF-beta target-gene transcription. As a modulator of the nodal signaling cascade, this gene plays a critical role in the induction of mesoderm during embryonic development. Alternative splicing of this gene results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Jul 2012],

Gene Name: RNF111

Protein Name: E3 ubiquitin-protein ligase Arkadia

Molecular Weight: 108 kDa

Gene ID: 54778

OMIM: 605840

UniProt: Q6ZNA4