NKX2-8 antibody (AA 20-69)

Catalog No. ABIN1451871

The Rabbit Polyclonal anti-NKX2-8 antibody (ABIN1451871) specifically detects NKX2-8 in WB and ELISA. The antibody is reactive with Human, Mouse and Rat samples.

Quick Overview for NKX2-8 antibody (AA 20-69) (ABIN1451871)

Target: NKX2-8 (NK2 Homeobox 8 (NKX2-8))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This NKX2-8 antibody is un-conjugated

Application: Western Blotting (WB), ELISA

Product Details anti-NKX2-8 Antibody

Binding Specificity: AA 20-69

Purpose: Nkx-2.8 Antibody

Specificity: Nkx-2.8 Polyclonal Antibody detects endogenous levels of Nkx-2.8 protein.

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Immunogen: The antiserum was produced against synthesized peptide derived from human NKX28. AA range:20-69

Isotype: IgG

Application Details

Application Notes: WB 1:500 - 1:2000. ELISA: 1:40000. Not yet tested in other applications.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: Liquid in PBS containing 50 % glycerol, 0.5 % BSA and 0.02 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C/1 year

Expiry Date: 12 months

Target Details for NKX2-8

Target: NKX2-8 (NK2 Homeobox 8 (NKX2-8))

Alternative Name: NKX28

Background:

Background: The protein encoded by this gene is a homeobox-containing developmental regulator associated with liver development. The encoded protein binds to the alpha-fetoprotein (AFP) gene promoter and increases the expression of AFP. This gene is overexpressed in some lung cancers and is linked to poor patient survival, possibly due to its resistance to cisplatin. This gene is aberrantly methylated in pancreatic cancer, deleted in squamous cell lung carcinomas, and acts as a tumor suppressor in esophageal cancer. Mutations in this gene may also be a cause of neural tube defects. [provided by RefSeq, Dec 2015],

Gene Name: NKX2-8

Protein Name: Homeobox protein Nkx-2.8

Molecular Weight: 25 kDa

Gene ID: 26257

OMIM: 603245

UniProt: Q8IUT7