SETMAR antibody (AA 350-400)

Catalog No. ABIN1451979

The Rabbit Polyclonal anti-SETMAR antibody (ABIN1451979) specifically detects SETMAR in ELISA, IHC and IF. The antibody is reactive with Human, Mouse and Rat samples.

Quick Overview for SETMAR antibody (AA 350-400) (ABIN1451979)

Target: SETMAR (SET Domain and Mariner Transposase Fusion Gene (SETMAR))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This SETMAR antibody is un-conjugated

Application: ELISA, Immunohistochemistry (IHC), Immunofluorescence (IF)

Product Details anti-SETMAR Antibody

Binding Specificity: AA 350-400

Purpose: SETMAR Antibody

Specificity: SETMAR Polyclonal Antibody detects endogenous levels of SETMAR protein.

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Purity: > 95 %

Immunogen: The antiserum was produced against synthesized peptide derived from human SETMAR. AA range:350-400

Isotype: IgG

Application Details

Application Notes: IHC 1:100 - 1:300. ELISA: 1:40000.. IF 1:50-200

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: Liquid in PBS containing 50 % glycerol, 0.5 % BSA and 0.02 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C/1 year

Expiry Date: 12 months

Target Details for SETMAR

Target: SETMAR (SET Domain and Mariner Transposase Fusion Gene (SETMAR))

Alternative Name: SETMAR

Background:

Synonyms: SETMAR, Histone-lysine N-methyltransferase SETMAR, SET domain and mariner transposase fusion gene-containing protein, HsMar1, Metnase

Background: This gene encodes a fusion protein that contains an N-terminal histone-lysine N-methyltransferase domain and a C-terminal mariner transposase domain. The encoded protein binds DNA and functions in DNA repair activities including non-homologous end joining and double strand break repair. The SET domain portion of this protein specifically methylates histone H3 lysines 4 and 36. This gene exists as a fusion gene only in anthropoid primates, other organisms lack mariner transposase domain. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Jan 2013],

Gene Name: SETMAR

Protein Name: Histone-lysine N-methyltransferase SETMAR

Molecular Weight: 76 kDa

Gene ID: 6419

OMIM: 609834

UniProt: Q53H47

Pathways: Positive Regulation of Response to DNA Damage Stimulus