C1R antibody (Cleaved-Arg463)

Catalog No. ABIN1452252

The Rabbit Polyclonal anti-C1R antibody (ABIN1452252) specifically detects C1R in WB and ELISA. The antibody is reactive with Human, Mouse and Rat samples.

Quick Overview for C1R antibody (Cleaved-Arg463) (ABIN1452252)

Target: C1R (Complement Component 1, R Subcomponent (C1R))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This C1R antibody is un-conjugated

Application: Western Blotting (WB), ELISA

Product Details anti-C1R Antibody

Binding Specificity: AA 414-463, Cleaved-Arg463

Purpose: Cleaved-C1r HC (R463) Antibody

Specificity: Cleaved-C1r HC (R463) Polyclonal Antibody detects endogenous levels of fragment of activated C1r HC protein resulting from cleavage adjacent to R463.

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Immunogen: The antiserum was produced against synthesized peptide derived from human C1R. AA range:414-463

Isotype: IgG

Application Details

Application Notes: WB 1:500 - 1:2000. ELISA: 1:10000. Not yet tested in other applications.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: Liquid in PBS containing 50 % glycerol, 0.5 % BSA and 0.02 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C/1 year

Expiry Date: 12 months

Target Details for C1R

Target: C1R (Complement Component 1, R Subcomponent (C1R))

Alternative Name: C1R

Background:

Synonyms: C1R, Complement C1r subcomponent, Complement component 1 subcomponent r

Background: catalytic activity:Selective cleavage of Lys(or Arg)-|-Ile bond in complement subcomponent C1s to form the active form of C1s (EC 3.4.21.42).,function:C1r B chain is a serine protease that combines with C1q and C1s to form C1, the first component of the classical pathway of the complement system.,polymorphism:Complement component C1r deficiency [MIM:216950] leads to the failure of the classical complement system activation pathway (C1 deficiency). Individuals with C1 deficiency are highly susceptible to infections by microorganisms and have greater risk in developing autoimmune diseases such as systemic lupus erythematosus (SLE).,PTM:The iron and 2-oxoglutarate dependent 3-hydroxylation of aspartate and asparagine is (R) stereospecific within EGF domains.,similarity:Belongs to the peptidase S1 family.,similarity:Contains 1 EGF-like domain.,similarity:Contains 1 peptidase S1 domain.,similarity:Contains 2 CUB domains.,similarity:Contains 2 Sushi (CCP/SCR) domains.,subunit:C1 is a calcium-dependent trimolecular complex of C1q, C1r and C1s in the molar ration of 1:2:2. C1r is a dimer of identical chains, each of which is activated by cleavage into two chains, A and B, connected by disulfide bonds.,

Gene Name: C1R

Protein Name: Complement C1r subcomponent

Molecular Weight: 80 kDa

Gene ID: 715

OMIM: 216950

UniProt: P00736

Pathways: Complement System