ITIH2 antibody (Cleaved-Asp702)

Catalog No. ABIN1452255

The Rabbit Polyclonal anti-ITIH2 antibody (ABIN1452255) specifically detects ITIH2 in WB and ELISA. The antibody is reactive with Human, Mouse and Rat samples.

Quick Overview for ITIH2 antibody (Cleaved-Asp702) (ABIN1452255)

Target: ITIH2 (Inter-alpha Globulin Inhibitor H2 Polypeptide (ITIH2))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This ITIH2 antibody is un-conjugated

Application: Western Blotting (WB), ELISA

Product Details anti-ITIH2 Antibody

Binding Specificity: AA 653-702, Cleaved-Asp702

Purpose: Cleaved-ITI-H2 (D702) Antibody

Specificity: Cleaved-ITI-H2 (D702) Polyclonal Antibody detects endogenous levels of fragment of activated ITI-H2 protein resulting from cleavage adjacent to D702.

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Immunogen: The antiserum was produced against synthesized peptide derived from human ITIH2. AA range:653-702

Isotype: IgG

Application Details

Application Notes: WB 1:500 - 1:2000. ELISA: 1:10000. Not yet tested in other applications.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: Liquid in PBS containing 50 % glycerol, 0.5 % BSA and 0.02 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C/1 year

Expiry Date: 12 months

Target Details for ITIH2

Target: ITIH2 (Inter-alpha Globulin Inhibitor H2 Polypeptide (ITIH2))

Alternative Name: ITIH2

Background:

Synonyms: ITIH2, IGHEP2, Inter-alpha-trypsin inhibitor heavy chain H2, ITI heavy chain H2, ITI-HC2, Inter-alpha-inhibitor heavy chain 2, Inter-alpha-trypsin inhibitor complex component II, Serum-derived hyaluronan-associated protein, SHAP

Background: The inter-alpha-trypsin inhibitors (ITI) are a family of structurally related plasma serine protease inhibitors involved in extracellular matrix stabilization and in prevention of tumor metastasis. The ITI family contains multiple proteins made up of a light chain (see MIM 176870) and a variable number of heavy chains (Salier et al., 1987 [PubMed 2446322], Himmelfarb et al., 2004 [PubMed 14744536]).[supplied by OMIM, Nov 2009],

Gene Name: ITIH2

Protein Name: Inter-alpha-trypsin inhibitor heavy chain H2

Molecular Weight: 106 kDa

Gene ID: 3698

OMIM: 146640

UniProt: P19823

Pathways: Glycosaminoglycan Metabolic Process