GJB2 antibody (AA 45-94)

Catalog No. ABIN1453152

The Rabbit Polyclonal anti-GJB2 antibody (ABIN1453152) specifically detects GJB2 in WB and ELISA. The antibody is reactive with Human, Mouse and Rat samples.

Quick Overview for GJB2 antibody (AA 45-94) (ABIN1453152)

Target: GJB2 (Gap Junction Protein, beta 2, 26kDa (GJB2))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This GJB2 antibody is un-conjugated

Application: Western Blotting (WB), ELISA

Product Details anti-GJB2 Antibody

Binding Specificity: AA 45-94

Purpose: Connexin-26 Antibody

Specificity: Connexin-26 Polyclonal Antibody detects endogenous levels of Connexin-26 protein.

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Immunogen: The antiserum was produced against synthesized peptide derived from human Connexin-26. AA range:45-94

Isotype: IgG

Application Details

Application Notes: WB 1:500 - 1:2000. ELISA: 1:5000. Not yet tested in other applications.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: Liquid in PBS containing 50 % glycerol, 0.5 % BSA and 0.02 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C/1 year

Expiry Date: 12 months

Target Details for GJB2

Target: GJB2 (Gap Junction Protein, beta 2, 26kDa (GJB2))

Alternative Name: Connexin-26

Background:

Synonyms: GJB2, Gap junction beta-2 protein, Connexin-26, Cx26

Background: This gene encodes a member of the gap junction protein family. The gap junctions were first characterized by electron microscopy as regionally specialized structures on plasma membranes of contacting adherent cells. These structures were shown to consist of cell-to-cell channels that facilitate the transfer of ions and small molecules between cells. The gap junction proteins, also known as connexins, purified from fractions of enriched gap junctions from different tissues differ. According to sequence similarities at the nucleotide and amino acid levels, the gap junction proteins are divided into two categories, alpha and beta. Mutations in this gene are responsible for as much as 50 % of pre-lingual, recessive deafness. [provided by RefSeq, Oct 2008],

Gene Name: GJB2

Protein Name: Gap junction beta-2 protein

Molecular Weight: 26 kDa

Gene ID: 2706

OMIM: 121011

UniProt: P29033

Pathways: Sensory Perception of Sound, Cell-Cell Junction Organization