POT1 antibody (AA 247-296)

Catalog No. ABIN1453800

The Rabbit Polyclonal anti-POT1 antibody (ABIN1453800) specifically detects POT1 in WB and IHC. The antibody is reactive with Human and Monkey samples.

Quick Overview for POT1 antibody (AA 247-296) (ABIN1453800)

Target: POT1 (Protection of Telomeres 1 (POT1))

Reactivity: Human, Monkey

Host: Rabbit

Clonality: Polyclonal

Conjugate: This POT1 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC)

Product Details anti-POT1 Antibody

Binding Specificity: AA 247-296

Purpose: POT1 Antibody

Specificity: POT1 Polyclonal Antibody detects endogenous levels of POT1 protein.

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Immunogen: The antiserum was produced against synthesized peptide derived from human POT1. AA range:247-296

Isotype: IgG

Application Details

Application Notes: WB 1:500-2000,IHC 1:50-300

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: Liquid in PBS containing 50 % glycerol, 0.5 % BSA and 0.02 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C/1 year

Expiry Date: 12 months

Target Details for POT1

Target: POT1 (Protection of Telomeres 1 (POT1))

Alternative Name: POT1

Background:

Synonyms: POT1, Protection of telomeres protein 1, hPot1, POT1-like telomere end-binding protein

Background: protection of telomeres 1(POT1) Homo sapiens This gene is a member of the telombin family and encodes a nuclear protein involved in telomere maintenance. Specifically, this protein functions as a member of a multi-protein complex that binds to the TTAGGG repeats of telomeres, regulating telomere length and protecting chromosome ends from illegitimate recombination, catastrophic chromosome instability, and abnormal chromosome segregation. Increased transcriptional expression of this gene is associated with stomach carcinogenesis and its progression. Alternatively spliced transcript variants have been described. [provided by RefSeq, Jul 2008],

Gene Name: POT1

Protein Name: Protection of telomeres protein 1

Molecular Weight: 71 kDa

Gene ID: 25913

OMIM: 606478

UniProt: Q9NUX5

Pathways: Cell Division Cycle, Telomere Maintenance