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CD46 antibody (AA 40-320)

This Rabbit Polyclonal antibody specifically detects CD46 in WB, IHC and IF. It exhibits reactivity toward Human.
Catalog No. ABIN1512715

Quick Overview for CD46 antibody (AA 40-320) (ABIN1512715)

Target

See all CD46 Antibodies
CD46

Reactivity

  • 130
  • 37
  • 23
  • 11
  • 10
  • 3
Human

Host

  • 90
  • 63
  • 2
  • 1
Rabbit

Clonality

  • 79
  • 77
Polyclonal

Conjugate

  • 63
  • 17
  • 14
  • 10
  • 4
  • 4
  • 3
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
This CD46 antibody is un-conjugated

Application

  • 92
  • 87
  • 41
  • 40
  • 39
  • 24
  • 22
  • 14
  • 14
  • 9
  • 8
  • 5
  • 5
  • 2
  • 2
  • 1
  • 1
  • 1
  • 1
Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF)
  • Binding Specificity

    • 16
    • 10
    • 7
    • 6
    • 6
    • 4
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 40-320

    Sequence

    TFEAMELIGK PKPYYEIGER VDYKCKKGYF YIPPLATHTI CDRNHTWLPV SDDACYRETC PYIRDPLNGQ AVPANGTYEF GYQMHFICNE GYYLIGEEIL YCELKGSVAI WSGKPPICEK VLCTPPPKIK NGKHTFSEVE VFEYLDAVTY SCDPAPGPDP FSLIGESTIY CGDNSVWSRA APECKVVKCR FPVVENGKQI SGFGKKFYYK ATVMFECDKG FYLDGSDTIV CDSNSTWDPP VPKCLKVSTS STTKSPASSA SGPRPTYKPP VSNYPGYPKP E

    Cross-Reactivity

    Human, Mouse, Rat

    Characteristics

    Polyclonal Antibodies

    Purification

    Affinity purification

    Immunogen

    Recombinant fusion protein containing a sequence corresponding to amino acids 40-320 of human CD46 (NP_722548.1).

    Isotype

    IgG
  • Application Notes

    WB,1:500 - 1:2000,IHC,1:50 - 1:200,IF,1:50 - 1:200

    Restrictions

    For Research Use only
  • Format

    Liquid

    Buffer

    PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.

    Preservative

    Sodium azide

    Precaution of Use

    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

    Handling Advice

    Avoid freeze / thaw cycles

    Storage

    -20 °C

    Storage Comment

    Store at -20°C. Avoid freeze / thaw cycles.
  • Target

    CD46

    Alternative Name

    CD46

    Background

    The protein encoded by this gene is a type I membrane protein and is a regulatory part of the complement system. The encoded protein has cofactor activity for inactivation of complement components C3b and C4b by serum factor I, which protects the host cell from damage by complement. In addition, the encoded protein can act as a receptor for the Edmonston strain of measles virus, human herpesvirus-6, and type IV pili of pathogenic Neisseria. Finally, the protein encoded by this gene may be involved in the fusion of the spermatozoa with the oocyte during fertilization. Mutations at this locus have been associated with susceptibility to hemolytic uremic syndrome. Alternatively spliced transcript variants encoding different isoforms have been described.,AHUS2,MCP,MIC10,TLX,TRA2.10,CD46,Immunology & Inflammation,CD markers,Cell Intrinsic Innate Immunity Signaling Pathway,CD46

    Molecular Weight

    36 kDa/39 kDa/40 kDa/41 kDa/42 kDa/43 kDa/44 kDa

    Gene ID

    4179

    UniProt

    P15529

    Pathways

    Regulation of Actin Filament Polymerization
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