TDG antibody

Catalog No. ABIN1526109

This anti-TDG antibody is a Mouse Monoclonal antibody detecting TDG in WB and EIA. Suitable for Human.

Quick Overview for TDG antibody (ABIN1526109)

Target: TDG (Thymine-DNA Glycosylase (TDG))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This TDG antibody is un-conjugated

Application: Western Blotting (WB), Enzyme Immunoassay (EIA)

Clone: AT2F7

Product Details anti-TDG Antibody

Purification: Protein-A affinity chromatography

Isotype: IgG1

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1.0 mg/mL

Buffer: Phosphate-Buffered Saline ( pH 7.4) containing 10 % Glycerol, 0.02 % Sodium Azide.

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Target Details for TDG

Target: TDG (Thymine-DNA Glycosylase (TDG))

Alternative Name: TDG

Background: G/T mismatch-specific thymine DNA glycosylase is an enzyme that in humans is encoded by the TDG gene. Several bacterial proteins have strong sequence homology with this protein. The protein encoded by this gene belongs to the TDG/mug DNA glycosylase family. Thymine-DNA glycosylase (TDG) removes thymine moieties from G/T mismatches by hydrolyzing the carbon-nitrogen bond between the sugar-phosphate backbone of DNA and the mispaired thymine. With lower activity, this enzyme also removes thymine from C/T and T/T mispairings. TDG can also remove uracil and 5-bromouracil from mispairings with guanine. This enzyme plays a central role in cellular defense against genetic mutation caused by the spontaneous deamination of 5-methylcytosine and cytosine. This gene may have a pseudogene in the p arm of chromosome 12.Synonyms: G/T mismatch-specific thymine DNA glycosylase

Pathways: DNA Damage Repair, Chromatin Binding