Tryptophan Hydroxylase 1 antibody (pSer58)

Catalog No. ABIN1531637

The Rabbit Polyclonal anti-Tryptophan Hydroxylase 1 antibody is suitable to detect Tryptophan Hydroxylase 1 in samples from Human, Mouse and Rat. It has been validated for WB, ELISA, IHC and IF.

Quick Overview for Tryptophan Hydroxylase 1 antibody (pSer58) (ABIN1531637)

Target: Tryptophan Hydroxylase 1 (TPH1)

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Tryptophan Hydroxylase 1 antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Immunofluorescence (IF)

Product Details anti-Tryptophan Hydroxylase 1 Antibody

Binding Specificity: AA 26-75, pSer58

Purpose: TPH1 (phospho Ser58) Antibody

Specificity: Phospho-TPH1 (S58) Polyclonal Antibody detects endogenous levels of TPH1 protein only when phosphorylated at S58.

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Purity: > 95 %

Immunogen: The antiserum was produced against synthesized peptide derived from human Tryptophan Hydroxylase around the phosphorylation site of Ser58. AA range:26-75

Isotype: IgG

Application Details

Application Notes: WB 1:500 - 1:2000. IHC 1:100 - 1:300. ELISA: 1:10000.. IF 1:50-200

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: Liquid in PBS containing 50 % glycerol, 0.5 % BSA and 0.02 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C/1 year

Expiry Date: 12 months

Target Details for Tryptophan Hydroxylase 1

Target: Tryptophan Hydroxylase 1 (TPH1)

Alternative Name: Tryptophan Hydroxylase

Background:

Synonyms: TPH1, TPH, TPRH, TRPH, Tryptophan 5-hydroxylase 1, Tryptophan 5-monooxygenase 1

Background: This gene encodes a member of the aromatic amino acid hydroxylase family. The encoded protein catalyzes the first and rate limiting step in the biosynthesis of serotonin, an important hormone and neurotransmitter. Mutations in this gene have been associated with an elevated risk for a variety of diseases and disorders, including schizophrenia, somatic anxiety, anger-related traits, bipolar disorder, suicidal behavior, addictions, and others.[provided by RefSeq, Apr 2009],

Gene Name: TPH1

Protein Name: Tryptophan 5-hydroxylase 1

Molecular Weight: 50 kDa

Gene ID: 7166

OMIM: 191060

UniProt: P17752

Pathways: Feeding Behaviour