CSNK1A1 antibody (pTyr321)

Catalog No. ABIN1531736

The Rabbit Polyclonal anti-CSNK1A1 antibody is suitable to detect CSNK1A1 in samples from Human, Rat and Mouse. It has been validated for WB, IHC, ELISA and IF.

Quick Overview for CSNK1A1 antibody (pTyr321) (ABIN1531736)

Target: CSNK1A1 (Casein Kinase 1, alpha 1 (CSNK1A1))

Reactivity: Human, Rat, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This CSNK1A1 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC), ELISA, Immunofluorescence (IF)

Product Details anti-CSNK1A1 Antibody

Binding Specificity: AA 287-336, pTyr321

Purpose: Casein Kinase Iα (phospho Thr321) Antibody

Specificity: Phospho-Casein Kinase Iα (Y321) Polyclonal Antibody detects endogenous levels of Casein Kinase Iα protein only when phosphorylated at Y321.

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Purity: > 95 %

Immunogen: The antiserum was produced against synthesized peptide derived from human Casein Kinase I alpha around the phosphorylation site of Tyr321. AA range:287-336

Isotype: IgG

Application Details

Application Notes: WB 1:500 - 1:2000. IHC 1:100 - 1:300. ELISA: 1:5000.. IF 1:50-200

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: Liquid in PBS containing 50 % glycerol, 0.5 % BSA and 0.02 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C/1 year

Expiry Date: 12 months

Target Details for CSNK1A1

Target: CSNK1A1 (Casein Kinase 1, alpha 1 (CSNK1A1))

Alternative Name: Casein Kinase I alpha

Background:

Synonyms: CSNK1A1, Casein kinase I isoform alpha, CKI-alpha, CK1

Background: catalytic activity:ATP + a protein = ADP + a phosphoprotein.,function:Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates. It can phosphorylate a large number of proteins. Participates in Wnt signaling. Phosphorylates CTNNB1 on 'Ser-45'.,similarity:Belongs to the protein kinase superfamily.,similarity:Belongs to the protein kinase superfamily. CK1 Ser/Thr protein kinase family. Casein kinase I subfamily.,similarity:Contains 1 protein kinase domain.,subunit:Monomer. Interacts with the Axin complex.,

Gene Name: CSNK1A1

Protein Name: Casein kinase I isoform alpha

Molecular Weight: 38 kDa

Gene ID: 1452

OMIM: 600505

UniProt: P48729

Pathways: WNT Signaling, Hedgehog Signaling