PER2 antibody (pSer662)

Catalog No. ABIN1531748

The Rabbit Polyclonal anti-PER2 antibody is suitable to detect PER2 in samples from Human and Mouse. It has been validated for WB, IHC, ELISA and IF.

Quick Overview for PER2 antibody (pSer662) (ABIN1531748)

Target: PER2 (Period Circadian Protein 2 (PER2))

Reactivity: Human, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This PER2 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC), ELISA, Immunofluorescence (IF)

Product Details anti-PER2 Antibody

Binding Specificity: AA 636-685, pSer662

Purpose: Per2 (phospho Ser662) Antibody

Specificity: Phospho-Per2 (S662) Polyclonal Antibody detects endogenous levels of Per2 protein only when phosphorylated at S662.

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Purity: > 95 %

Immunogen: The antiserum was produced against synthesized peptide derived from human Period Circadian Protein 2 around the phosphorylation site of Ser662. AA range:636-685

Isotype: IgG

Application Details

Application Notes: WB 1:500 - 1:2000. IHC 1:100 - 1:300. ELISA: 1:5000.. IF 1:50-200

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: Liquid in PBS containing 50 % glycerol, 0.5 % BSA and 0.02 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C/1 year

Expiry Date: 12 months

Target Details for PER2

Target: PER2 (Period Circadian Protein 2 (PER2))

Alternative Name: Period Circadian Protein 2

Background:

Synonyms: PER2, KIAA0347, Period circadian protein homolog 2, hPER2, Circadian clock protein PERIOD 2

Background: This gene is a member of the Period family of genes and is expressed in a circadian pattern in the suprachiasmatic nucleus, the primary circadian pacemaker in the mammalian brain. Genes in this family encode components of the circadian rhythms of locomotor activity, metabolism, and behavior. This gene is upregulated by CLOCK/ARNTL heterodimers but then represses this upregulation in a feedback loop using PER/CRY heterodimers to interact with CLOCK/ARNTL. Polymorphisms in this gene may increase the risk of getting certain cancers and have been linked to sleep disorders. [provided by RefSeq, Jan 2014],

Gene Name: PER2

Protein Name: Period circadian protein homolog 2

Molecular Weight: 136 kDa

Gene ID: 8864

OMIM: 603426

UniProt: O15055