EPH Receptor A3 antibody (pTyr779, pTyr833)

Catalog No. ABIN1532042

The Rabbit Polyclonal anti-EPH Receptor A3 antibody (ABIN1532042) specifically detects EPH Receptor A3 in ELISA, IHC and IF. The antibody is reactive with Human, Mouse and Rat samples.

Quick Overview for EPH Receptor A3 antibody (pTyr779, pTyr833) (ABIN1532042)

Target: EPH Receptor A3 (EPHA3)

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This EPH Receptor A3 antibody is un-conjugated

Application: ELISA, Immunohistochemistry (IHC), Immunofluorescence (IF)

Product Details anti-EPH Receptor A3 Antibody

Binding Specificity: AA 746-795, pTyr779, pTyr833

Purpose: EphA3/4/5 (phospho Tyr779/833) Antibody

Specificity: Phospho-EphA3/4/5 (Y779/833) Polyclonal Antibody detects endogenous levels of EphA3/4/5 protein only when phosphorylated at Y779/833.

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Purity: > 95 %

Immunogen: The antiserum was produced against synthesized peptide derived from human EPHA3/4/5 around the phosphorylation site of Tyr779/833. AA range:746-795

Isotype: IgG

Application Details

Application Notes: IHC 1:100 - 1:300. ELISA: 1:10000.. IF 1:50-200

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: Liquid in PBS containing 50 % glycerol, 0.5 % BSA and 0.02 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C/1 year

Expiry Date: 12 months

Target Details for EPH Receptor A3

Target: EPH Receptor A3 (EPHA3)

Alternative Name: EPHA3/4/5

Background:

Synonyms: EPHA3, ETK, ETK1, HEK, TYRO4, Ephrin type-A receptor 3, EPH-like kinase 4, EK4, hEK4, HEK, Human embryo kinase, Tyrosine-protein kinase TYRO4, Tyrosine-protein kinase receptor ETK1, Eph-like tyrosine kinase 1, EPHA4, HEK8, SEK, TYRO1, Ephri

Background: This gene belongs to the ephrin receptor subfamily of the protein-tyrosine kinase family. EPH and EPH-related receptors have been implicated in mediating developmental events, particularly in the nervous system. Receptors in the EPH subfamily typically have a single kinase domain and an extracellular region containing a Cys-rich domain and 2 fibronectin type III repeats. The ephrin receptors are divided into 2 groups based on the similarity of their extracellular domain sequences and their affinities for binding ephrin-A and ephrin-B ligands.This gene encodes a protein that binds ephrin-A ligands. Two alternatively spliced transcript variants have been described for this gene. [provided by RefSeq, Jul 2008],

Gene Name: EPHA3/EPHA4/EPHA5

Protein Name: Ephrin type-A receptor 3/4/5

Molecular Weight: 110 kDa

Gene ID: 2042, 2043, 54764

OMIM: 114500

UniProt: P29320

Pathways: RTK Signaling, Regulation of Cell Size