Presenilin 1 antibody (pSer357)

Catalog No. ABIN1532166

The Rabbit Polyclonal anti-Presenilin 1 antibody has been validated for WB, ELISA and IHC. It is suitable to detect Presenilin 1 in samples from Human, Mouse and Rat.

Quick Overview for Presenilin 1 antibody (pSer357) (ABIN1532166)

Target: Presenilin 1 (PSEN1)

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Presenilin 1 antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunohistochemistry (IHC)

Product Details anti-Presenilin 1 Antibody

Binding Specificity: AA 323-372, pSer357

Specificity:

PSEN1 (Phospho-Ser357) Antibody detects endogenous levels of PSEN1 only when phosphorylated at Ser357.

PhosphorylationH:S357 M:S357 R:S358

Purification: The antibody was purified from rabbit antiserum by affinity-chromatography using phospho peptide. The antibody against non-phospho peptide was removed by chromatography using corresponding non-phospho peptide.

Purity: > 95 %

Immunogen: The antiserum was produced against synthesized peptide derived from human PSEN1 around the phosphorylation site of Ser357.

Isotype: IgG

Application Details

Application Notes: WB: 1:500~1:1000 IHC: 1:50~1:100 ELISA: 1:5000

Comment:

Unigene-Number: Hs.3260 (NCBI Gene Symbol: PSEN1)

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Stable at -20°C for at least 1 year.

Expiry Date: 12 months

Target Details for Presenilin 1

Target: Presenilin 1 (PSEN1)

Alternative Name: PSEN1

Background:

Synonyms: AD3, AD3H, presenilin 1, PS-1, PS1, PSN1, PSNL1, S182 protein

NCBI Gene Symbol: PSEN1

Molecular Weight: 52 kDa

Gene ID: 5663

OMIM: 104311

UniProt: P49768

Pathways: Notch Signaling, EGFR Signaling Pathway, Synaptic Vesicle Exocytosis, Dicarboxylic Acid Transport