PKC antibody (AA 623-672)

Catalog No. ABIN1532523

This Rabbit Polyclonal antibody specifically detects PKC in WB, IF, IHC and ELISA. It exhibits reactivity toward Human, Mouse and Rat.

Quick Overview for PKC antibody (AA 623-672) (ABIN1532523)

Target: PKC (Protein Kinase C (PKC))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This PKC antibody is un-conjugated

Application: Western Blotting (WB), Immunofluorescence (IF), Immunohistochemistry (IHC), ELISA

Product Details anti-PKC Antibody

Binding Specificity: AA 623-672

Purpose: PKC Antibody

Specificity: PKC Polyclonal Antibody detects endogenous levels of PKC protein.

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Purity: > 95 %

Immunogen: The antiserum was produced against synthesized peptide derived from human PKC. AA range:623-672

Isotype: IgG

Application Details

Application Notes: WB 1:500 - 1:2000. IHC 1:100 - 1:300. IF 1:200 - 1:1000. ELISA: 1:5000. Not yet tested in other applications.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: Liquid in PBS containing 50 % glycerol, 0.5 % BSA and 0.02 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C/1 year

Expiry Date: 12 months

Target Details for PKC

Target: PKC (Protein Kinase C (PKC))

Alternative Name: PKC

Background:

Synonyms: PRKCA, PKCA, PRKACA, Protein kinase C alpha type, PKC-A, PKC-alpha, PRKCB, PKCB, PRKCB1, Protein kinase C beta type, PKC-B, PKC-beta, PRKCD, Protein kinase C delta type, Tyrosine-protein kinase PRKCD, nPKC-delta, PRKCE, PKCE, Protein kinase

Background: Protein kinase C (PKC) is a family of serine- and threonine-specific protein kinases that can be activated by calcium and the second messenger diacylglycerol. PKC family members phosphorylate a wide variety of protein targets and are known to be involved in diverse cellular signaling pathways. PKC family members also serve as major receptors for phorbol esters, a class of tumor promoters. Each member of the PKC family has a specific expression profile and is believed to play a distinct role in cells.The protein encoded by this gene is one of the PKC family members. This kinase has been reported to play roles in many different cellular processes, such as cell adhesion, cell transformation, cell cycle checkpoint, and cell volume control. Knockout studies in mice suggest that this kinase may be a fundamental regulator of cardiac contractility and Ca(2+) handling in myocytes. [provided by RefSeq, Jul 2

Gene Name: PRKCA/PRKCB/PRKCD/PRKCE/PRKCG/PRKCH/PRKCQ/PRKCZ

Protein Name: Protein kinase C alpha type/Protein kinase C beta type/Protein kinase C delta type/Protein kinase C epsilon type/Protein kinase C gamma type/Protein kinase C eta type/Protein kinase C theta type/Protein kinase C zeta type

Molecular Weight: 76 kDa

Gene ID: 5578, 5579, 5580

OMIM: 176960

UniProt: P17252

Pathways: TCR Signaling, Regulation of G-Protein Coupled Receptor Protein Signaling, Positive Regulation of Response to DNA Damage Stimulus, Interaction of EGFR with phospholipase C-gamma, Phototransduction