Fibrillin 1 antibody (AA 2811-2860)

Catalog No. ABIN1533275

This Rabbit Polyclonal antibody specifically detects Fibrillin 1 in WB, IHC, ELISA and IF. It exhibits reactivity toward Human, Mouse and Rat.

Quick Overview for Fibrillin 1 antibody (AA 2811-2860) (ABIN1533275)

Target: Fibrillin 1 (FBN1)

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Fibrillin 1 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC), ELISA, Immunofluorescence (IF)

Product Details anti-Fibrillin 1 Antibody

Binding Specificity: AA 2811-2860

Purpose: FBN1 Antibody

Specificity: FBN1 Polyclonal Antibody detects endogenous levels of FBN1 protein.

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Purity: > 95 %

Immunogen: The antiserum was produced against synthesized peptide derived from human Fibrillin-1. AA range:2811-2860

Isotype: IgG

Application Details

Application Notes: WB 1:500 - 1:2000. IHC 1:100 - 1:300. ELISA: 1:20000.. IF 1:50-200

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: Liquid in PBS containing 50 % glycerol, 0.5 % BSA and 0.02 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C/1 year

Expiry Date: 12 months

Target Details for Fibrillin 1

Target: Fibrillin 1 (FBN1)

Alternative Name: Fibrillin-1

Background:

Synonyms: FBN1, FBN, Fibrillin-1

Background: This gene encodes a member of the fibrillin family of proteins. The encoded preproprotein is proteolytically processed to generate two proteins including the extracellular matrix component fibrillin-1 and the protein hormone asprosin. Fibrillin-1 is an extracellular matrix glycoprotein that serves as a structural component of calcium-binding microfibrils. These microfibrils provide force-bearing structural support in elastic and nonelastic connective tissue throughout the body. Asprosin, secreted by white adipose tissue, has been shown to regulate glucose homeostasis. Mutations in this gene are associated with Marfan syndrome and the related MASS phenotype, as well as ectopia lentis syndrome, Weill-Marchesani syndrome, Shprintzen-Goldberg syndrome and neonatal progeroid syndrome. [provided by RefSeq, Apr 2016],

Gene Name: FBN1

Protein Name: Fibrillin-1

Molecular Weight: 312 kDa

Gene ID: 2200

OMIM: 134797

UniProt: P35555

Pathways: Maintenance of Protein Location, SARS-CoV-2 Protein Interactome