KSR2 antibody (AA 671-720)

Catalog No. ABIN1533965

The Rabbit Polyclonal anti-KSR2 antibody (ABIN1533965) specifically detects KSR2 in WB, ELISA, IHC and IF. The antibody is reactive with Human and Mouse samples.

Quick Overview for KSR2 antibody (AA 671-720) (ABIN1533965)

Target: KSR2 (Kinase Suppressor of Ras 2 (KSR2))

Reactivity: Human, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This KSR2 antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Immunofluorescence (IF)

Product Details anti-KSR2 Antibody

Binding Specificity: AA 671-720

Purpose: Ksr2 Antibody

Specificity: Ksr2 Polyclonal Antibody detects endogenous levels of Ksr2 protein.

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Purity: > 95 %

Immunogen: The antiserum was produced against synthesized peptide derived from human KSR2. AA range:671-720

Isotype: IgG

Application Details

Application Notes: WB 1:500 - 1:2000. IHC 1:100 - 1:300. IF 1:200 - 1:1000. ELISA: 1:40000. Not yet tested in other applications.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: Liquid in PBS containing 50 % glycerol, 0.5 % BSA and 0.02 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C/1 year

Expiry Date: 12 months

Target Details for KSR2

Target: KSR2 (Kinase Suppressor of Ras 2 (KSR2))

Alternative Name: KSR2

Background:

Synonyms: KSR2, Kinase suppressor of Ras 2, hKSR2

Background: domain:The protein kinase domain is predicted to be catalytically inactive.,function:Location-regulated scaffold connecting MEK to RAF. Blocks MAP3K8 kinase activity and MAP3K8-mediated signaling. Acts as a negative regulator of MAP3K3-mediated activation of ERK, JNK and NF-kappa-B pathways, inhibiting MAP3K3-mediated interleukin-8 production.,PTM:Phosphorylated on Ser-474 by MARK3.,similarity:Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family.,similarity:Contains 1 phorbol-ester/DAG-type zinc finger.,similarity:Contains 1 protein kinase domain.,subunit:Interacts with MAP2K1, MAP3K8, MAPK, RAS and RAF.,tissue specificity:Mainly expressed in brain and kidney.,

Gene Name: KSR2

Protein Name: Kinase suppressor of Ras 2

Molecular Weight: 107 kDa

Gene ID: 283455

OMIM: 610737

UniProt: Q6VAB6