BRSK1 antibody (AA 361-410)

Catalog No. ABIN1534022

The Rabbit Polyclonal anti-BRSK1 antibody (ABIN1534022) specifically detects BRSK1 in WB, ELISA and IF. The antibody is reactive with Human and Mouse samples.

Quick Overview for BRSK1 antibody (AA 361-410) (ABIN1534022)

Target: BRSK1 (BR Serine/threonine Kinase 1 (BRSK1))

Reactivity: Human, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This BRSK1 antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunofluorescence (IF)

Product Details anti-BRSK1 Antibody

Binding Specificity: AA 361-410

Purpose: BRSK1 Antibody

Specificity: BRSK1 Polyclonal Antibody detects endogenous levels of BRSK1 protein.

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Purity: > 95 %

Immunogen: The antiserum was produced against synthesized peptide derived from human BRSK1. AA range:361-410

Isotype: IgG

Application Details

Application Notes: WB 1:500 - 1:2000. IF 1:200 - 1:1000. ELISA: 1:5000. Not yet tested in other applications.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: Liquid in PBS containing 50 % glycerol, 0.5 % BSA and 0.02 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C/1 year

Expiry Date: 12 months

Target Details for BRSK1

Target: BRSK1 (BR Serine/threonine Kinase 1 (BRSK1))

Alternative Name: BRSK1

Background:

Synonyms: BRSK1, KIAA1811, SAD1, SADB, Serine/threonine-protein kinase BRSK1, Brain-selective kinase 1, Brain-specific serine/threonine-protein kinase 1, BR serine/threonine-protein kinase 1, Serine/threonine-protein kinase SAD-B, Synapses of Amphids

Background: catalytic activity:ATP + a protein = ADP + a phosphoprotein.,cofactor:Magnesium.,enzyme regulation:Activated by phosphorylation on Thr-205 by STK11 in complex with STE20-related adapter-alpha (STRAD alpha) pseudo kinase and CAB39.,function:Required for the polarization of forebrain neurons which endows axons and dendrites with distinct properties, possibly by locally regulating phosphorylation of microtubule-associated proteins (By similarity). May be involved in the regulation of G2/M arrest in response to UV- or methyl methane sulfonate (MMS)-induced, but not IR-induced, DNA damage. Phosphorylates WEE1 and CDC25B in vitro and CDC25C in vitro and in vivo.,similarity:Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. AMPK subfamily.,similarity:Contains 1 protein kinase domain.,similarity:Contains 1 UBA domain.,subcellular location:Nuclear in the absence of DNA damage. Translocated to the nucleus in response to UV- or MMS-induced DNA damage.,tissue specificity:Widely expressed, with highest levels in brain and testis. Protein levels remain constant throughout the cell cycle.,

Gene Name: BRSK1

Protein Name: Serine/threonine-protein kinase BRSK1

Molecular Weight: 86 kDa

Gene ID: 84446

OMIM: 609235

UniProt: Q8TDC3