ADCY5/6 antibody (AA 931-980)

Catalog No. ABIN1534255

The Rabbit Polyclonal anti-ADCY5/6 antibody is suitable to detect ADCY5/6 in samples from Human, Mouse and Rat. It has been validated for ELISA, IF and IHC.

Quick Overview for ADCY5/6 antibody (AA 931-980) (ABIN1534255)

Target: ADCY5/6 (Adenylate Cyclase 5/6 (ADCY5/6))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This ADCY5/6 antibody is un-conjugated

Application: ELISA, Immunofluorescence (IF), Immunohistochemistry (IHC)

Product Details anti-ADCY5/6 Antibody

Binding Specificity: AA 931-980

Purpose: A Cyclase V/VI Antibody

Specificity: A Cyclase V/VI Polyclonal Antibody detects endogenous levels of A Cyclase V/VI protein.

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Purity: > 95 %

Immunogen: The antiserum was produced against synthesized peptide derived from human ADCY5/6. AA range:931-980

Isotype: IgG

Application Details

Application Notes: IHC 1:100 - 1:300. IF 1:200 - 1:1000. ELISA: 1:20000. Not yet tested in other applications.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: Liquid in PBS containing 50 % glycerol, 0.5 % BSA and 0.02 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C/1 year

Expiry Date: 12 months

Target Details for ADCY5/6

Target: ADCY5/6 (Adenylate Cyclase 5/6 (ADCY5/6))

Background:

Synonyms: ADCY6, KIAA0422, Adenylate cyclase type 6, ATP pyrophosphate-lyase 6, Adenylate cyclase type VI, Adenylyl cyclase 6, Ca(2+)-inhibitable adenylyl cyclase, ADCY5, Adenylate cyclase type 5, ATP pyrophosphate-lyase 5, Adenylate cyclase type V,

Background: This gene encodes a member of the adenylyl cyclase family of proteins, which are required for the synthesis of cyclic AMP. All members of this family have an intracellular N-terminus, a tandem repeat of six transmembrane domains separated by a cytoplasmic loop, and a C-terminal cytoplasmic domain. The two cytoplasmic regions bind ATP and form the catalytic core of the protein. Adenylyl cyclases are important effectors of transmembrane signaling pathways and are regulated by the activity of G protein coupled receptor signaling. This protein belongs to a small subclass of adenylyl cyclase proteins that are functionally related and are inhibited by protein kinase A, calcium ions and nitric oxide. A mutation in this gene is associated with arthrogryposis multiplex congenita. [provided by RefSeq, May 2015],

Gene Name: ADCY5/ADCY6

Protein Name: Adenylate cyclase type 5/6

Molecular Weight: 130 kDa

Gene ID: 112, 111

OMIM: 600294

UniProt: O43306