ADCY5/6 antibody (AA 900-980)

Catalog No. ABIN7219256

This Rabbit Polyclonal antibody specifically detects ADCY5/6 in ELISA, IF and IHC. It exhibits reactivity toward Human, Mouse and Rat.

Quick Overview for ADCY5/6 antibody (AA 900-980) (ABIN7219256)

Target: ADCY5/6 (Adenylate Cyclase 5/6 (ADCY5/6))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This ADCY5/6 antibody is un-conjugated

Application: ELISA, Immunofluorescence (IF), Immunohistochemistry (IHC)

Product Details anti-ADCY5/6 Antibody

Binding Specificity: AA 900-980

Purpose: Rabbit Anti-A Cyclase V/VI Polyclonal Antibody

Specificity: A Cyclase V/VI Polyclonal Antibody detects endogenous levels of A Cyclase V/VI protein.

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Immunogen: Synthesized peptide derived from the C-terminal region of human A Cyclase V/VI at AA range: 900-980

Isotype: IgG

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator. Suggested starting dilutions are as follows: IHC 1:100-1:300,IF 1:200-1:1000,ELISA 1:20000,Not yet tested in other applications.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: Liquid in PBS containing 50 % glycerol, 0.5 % BSA and 0.02 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Stable for one year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Aliquot to avoid repeated freezing and thawing.

Expiry Date: 12 months

Target Details for ADCY5/6

Target: ADCY5/6 (Adenylate Cyclase 5/6 (ADCY5/6))

Alternative Name: A Cyclase V/VI

Background: ADCY6, KIAA0422, Adenylate cyclase type 6, ATP pyrophosphate-lyase 6, Adenylate cyclase type VI, Adenylyl cyclase 6, Ca(2+)-inhibitable adenylyl cyclase, ADCY5, Adenylate cyclase type 5, ATP pyrophosphate-lyase 5, Adenylate cyclase type V,ADCY6 encodes a member of the adenylyl cyclase family of proteins, which are required for the synthesis of cyclic AMP. All members of this family have an intracellular N-terminus, a tandem repeat of six transmembrane domains separated by a cytoplasmic loop, and a C-terminal cytoplasmic domain. The two cytoplasmic regions bind ATP and form the catalytic core of the protein. Adenylyl cyclases are important effectors of transmembraneAdenylate cyclase type 5/6 belongs to a small subclass of adenylyl cyclase proteins that are functionally related and are inhibited by protein kinase A, calcium ions and nitric oxide. A mutation in this gene is associated with arthrogryposis multiplex congenita.

Gene ID: 112, 111

UniProt: O43306, O95622