FGF23 antibody (AA 151-200)

Catalog No. ABIN1534408

There is 1 publication for this product available. The Rabbit Polyclonal anti-FGF23 antibody is suitable to detect FGF23 in samples from Human, Rat and Mouse. It has been validated for WB, ELISA and IF.

Quick Overview for FGF23 antibody (AA 151-200) (ABIN1534408)

Target: FGF23 (Fibroblast Growth Factor 23 (FGF23))

Reactivity: Human, Rat, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This FGF23 antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunofluorescence (IF)

Product Details anti-FGF23 Antibody

Binding Specificity: AA 151-200

Purpose: FGF-23 Antibody

Specificity: FGF-23 Polyclonal Antibody detects endogenous levels of FGF-23 protein.

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Purity: > 95 %

Immunogen: The antiserum was produced against synthesized peptide derived from human FGF23. AA range:151-200

Isotype: IgG

Application Details

Application Notes: WB 1:500 - 1:2000. ELISA: 1:20000. IF 1:100-300 Not yet tested in other applications.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: Liquid in PBS containing 50 % glycerol, 0.5 % BSA and 0.02 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C/1 year

Expiry Date: 12 months

References for anti-FGF23 antibody (ABIN1534408)

Sun, Zou, Yang, Morita, Gong, Shiba, Akagawa, Yuan: "Inorganic polyphosphates stimulate FGF23 expression through the FGFR pathway." in: Biochemical and biophysical research communications, Vol. 428, Issue 2, pp. 298-302, (2012) (PubMed).

Target Details for FGF23

Target: FGF23 (Fibroblast Growth Factor 23 (FGF23))

Alternative Name: FGF23

Background:

Synonyms: FGF23, HYPF, Fibroblast growth factor 23, FGF-23, Phosphatonin, Tumor-derived hypophosphatemia-inducing factor

Background: This gene encodes a member of the fibroblast growth factor family of proteins, which possess broad mitogenic and cell survival activities and are involved in a variety of biological processes. The product of this gene regulates phosphate homeostasis and transport in the kidney. The full-length, functional protein may be deactivated via cleavage into N-terminal and C-terminal chains. Mutation of this cleavage site causes autosomal dominant hypophosphatemic rickets (ADHR). Mutations in this gene are also associated with hyperphosphatemic familial tumoral calcinosis (HFTC). [provided by RefSeq, Feb 2013],

Gene Name: FGF23

Protein Name: Fibroblast growth factor 23

Molecular Weight: 27 kDa

Gene ID: 8074

OMIM: 193100

UniProt: Q9GZV9

Pathways: RTK Signaling, Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway, Negative Regulation of Hormone Secretion