MLH3 antibody (AA 521-570)

Catalog No. ABIN1534469

The Rabbit Polyclonal anti-MLH3 antibody (ABIN1534469) specifically detects MLH3 in WB, ELISA, IHC and IF. The antibody is reactive with Human, Mouse and Rat samples.

Quick Overview for MLH3 antibody (AA 521-570) (ABIN1534469)

Target: MLH3 (MutL Homolog 3 (MLH3))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This MLH3 antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Immunofluorescence (IF)

Product Details anti-MLH3 Antibody

Binding Specificity: AA 521-570

Purpose: MLH3 Antibody

Specificity: MLH3 Polyclonal Antibody detects endogenous levels of MLH3 protein.

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Purity: > 95 %

Immunogen: The antiserum was produced against synthesized peptide derived from human MLH3. AA range:521-570

Isotype: IgG

Application Details

Application Notes: WB 1:500 - 1:2000. IHC 1:100 - 1:300. ELISA: 1:40000.. IF 1:50-200

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: Liquid in PBS containing 50 % glycerol, 0.5 % BSA and 0.02 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C/1 year

Expiry Date: 12 months

Target Details for MLH3

Target: MLH3 (MutL Homolog 3 (MLH3))

Alternative Name: MLH3

Background:

Synonyms: MLH3, DNA mismatch repair protein Mlh3, MutL protein homolog 3

Background: This gene is a member of the MutL-homolog (MLH) family of DNA mismatch repair (MMR) genes. MLH genes are implicated in maintaining genomic integrity during DNA replication and after meiotic recombination.The protein encoded by this gene functions as a heterodimer with other family members. Somatic mutations in this gene frequently occur in tumors exhibiting microsatellite instability, and germline mutations have been linked to hereditary nonpolyposis colorectal cancer type 7 (HNPCC7). Several alternatively spliced transcript variants have been identified, but the full-length nature of only two transcript variants has been determined. [provided by RefSeq, Jul 2008],

Gene Name: MLH3

Protein Name: DNA mismatch repair protein Mlh3

Molecular Weight: 163 kDa

Gene ID: 27030

OMIM: 114500

UniProt: Q9UHC1

Pathways: Chromatin Binding