CLDN8 antibody (AA 81-130)

Catalog No. ABIN1534783

The Rabbit Polyclonal anti-CLDN8 antibody is suitable to detect CLDN8 in samples from Human, Mouse and Rat. It has been validated for WB and ELISA.

Quick Overview for CLDN8 antibody (AA 81-130) (ABIN1534783)

Target: CLDN8 (Claudin 8 (CLDN8))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This CLDN8 antibody is un-conjugated

Application: Western Blotting (WB), ELISA

Product Details anti-CLDN8 Antibody

Binding Specificity: AA 81-130

Purpose: Claudin-8 Antibody

Specificity: Claudin-8 Polyclonal Antibody detects endogenous levels of Claudin-8 protein.

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Purity: > 95 %

Immunogen: The antiserum was produced against synthesized peptide derived from human CLDN8. AA range:81-130

Isotype: IgG

Application Details

Application Notes: WB 1:500 - 1:2000. ELISA: 1:5000. Not yet tested in other applications.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: Liquid in PBS containing 50 % glycerol, 0.5 % BSA and 0.02 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C/1 year

Expiry Date: 12 months

Target Details for CLDN8

Target: CLDN8 (Claudin 8 (CLDN8))

Alternative Name: CLDN8

Background:

Synonyms: CLDN8, Claudin-8

Background: This gene encodes a member of the claudin family. Claudins are integral membrane proteins and components of tight junction strands. Tight junction strands serve as a physical barrier to prevent solutes and water from passing freely through the paracellular space between epithelial or endothelial cell sheets, and also play critical roles in maintaining cell polarity and signal transductions. This protein plays important roles in the paracellular cation barrier of the distal renal tubule, and in the paracellular barrier to prevent sodium back-leakage in distal colon. Differential expression of this gene has been observed in colorectal carcinoma and renal cell tumors, and along with claudin-7, is an immunohistochemical marker for the differential diagnosis of chromophobe renal cell carcinoma and renal oncocytoma.[provided by RefSeq, May 2010],

Gene Name: CLDN8

Protein Name: Claudin-8

Molecular Weight: 24 kDa

Gene ID: 9073

OMIM: 611231

UniProt: P56748

Pathways: Hepatitis C