ZNRF2 antibody (AA 161-210)

Catalog No. ABIN1534873

The Rabbit Polyclonal anti-ZNRF2 antibody is suitable to detect ZNRF2 in samples from Human and Mouse. It has been validated for IF, IHC and ELISA.

Quick Overview for ZNRF2 antibody (AA 161-210) (ABIN1534873)

Target: ZNRF2 (Zinc and Ring Finger 2 (ZNRF2))

Reactivity: Human, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This ZNRF2 antibody is un-conjugated

Application: Immunofluorescence (IF), Immunohistochemistry (IHC), ELISA

Product Details anti-ZNRF2 Antibody

Binding Specificity: AA 161-210

Purpose: ZNRF2 Antibody

Specificity: ZNRF2 Polyclonal Antibody detects endogenous levels of ZNRF2 protein.

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Purity: > 95 %

Immunogen: The antiserum was produced against synthesized peptide derived from human ZNRF2. AA range:161-210

Isotype: IgG

Application Details

Application Notes: IHC 1:100 - 1:300. IF 1:200 - 1:1000. ELISA: 1:20000. Not yet tested in other applications.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: Liquid in PBS containing 50 % glycerol, 0.5 % BSA and 0.02 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C/1 year

Expiry Date: 12 months

Target Details for ZNRF2

Target: ZNRF2 (Zinc and Ring Finger 2 (ZNRF2))

Alternative Name: ZNRF2

Background:

Synonyms: ZNRF2, RNF202, E3 ubiquitin-protein ligase ZNRF2, Protein Ells2, RING finger protein 202, Zinc/RING finger protein 2

Background: domain:The RING-type zinc finger domain is required for E3 ligase activity.,function:May play a role in the establisment and maintenance of neuronal transmission and plasticity via its ubiquitin ligase activity. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfer the ubiquitin to targeted substrates.,pathway:Protein modification, protein ubiquitination.,PTM:Phosphorylated upon DNA damage, probably by ATM or ATR.,similarity:Contains 1 RING-type zinc finger.,subcellular location:Present in presynaptic plasma membranes in neurons.,subunit:Interacts with UBE2N.,tissue specificity:Highly expressed in the brain, with higher expression during development than in adult. Expressed also in mammary glands, testis, colon and kidney.,

Gene Name: ZNRF2

Protein Name: E3 ubiquitin-protein ligase ZNRF2

Molecular Weight: 24 kDa

Gene ID: 223082

OMIM: 612061

UniProt: Q8NHG8

Pathways: Synaptic Membrane