Nesprin3 antibody (AA 169-218)

Catalog No. ABIN1535082

This Rabbit Polyclonal antibody specifically detects Nesprin3 in WB, ELISA and IF. It exhibits reactivity toward Human and Mouse.

Quick Overview for Nesprin3 antibody (AA 169-218) (ABIN1535082)

Target: Nesprin3 (C14orf49) (Chromosome 14 Open Reading Frame 49 (C14orf49))

Reactivity: Human, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Nesprin3 antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunofluorescence (IF)

Product Details anti-Nesprin3 Antibody

Binding Specificity: AA 169-218

Purpose: Nesprin-3 Antibody

Specificity: Nesprin-3 Polyclonal Antibody detects endogenous levels of Nesprin-3 protein.

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Purity: > 95 %

Immunogen: The antiserum was produced against synthesized peptide derived from human C14orf49. AA range:169-218

Isotype: IgG

Application Details

Application Notes: WB 1:500 - 1:2000. IF 1:200 - 1:1000. ELISA: 1:40000. Not yet tested in other applications.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: Liquid in PBS containing 50 % glycerol, 0.5 % BSA and 0.02 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C/1 year

Expiry Date: 12 months

Target Details for Nesprin3

Target: Nesprin3 (C14orf49) (Chromosome 14 Open Reading Frame 49 (C14orf49))

Alternative Name: C14orf49

Background:

Synonyms: SYNE3, C14orf49, Nesprin-3, Nuclear envelope spectrin repeat protein 3

Background: function:Involved in the maintenance of nuclear organization and structural integrity. Probable anchoring protein which theters the nucleus to the cytoskeleton by binding PLEC1/Plectin which can associate with the intermediate filament system.,similarity:Belongs to the nesprin family.,similarity:Contains 1 KASH domain.,similarity:Contains 2 spectrin repeats.,subcellular location:Located at the rough reticulum endoplasmic (RER) in some cells.,subunit:Interacts with actin-binding domain of PLEC1/plectin.,

Gene Name: SYNE3

Protein Name: Nesprin-3

Molecular Weight: 112 kDa

Gene ID: 161176

OMIM: 610861

UniProt: Q6ZMZ3

Pathways: Maintenance of Protein Location