PVRL4 antibody (AA 312-361)

Catalog No. ABIN1535179

The Rabbit Polyclonal anti-PVRL4 antibody is suitable to detect PVRL4 in samples from Human, Mouse and Rat. It has been validated for WB and ELISA.

Quick Overview for PVRL4 antibody (AA 312-361) (ABIN1535179)

Target: PVRL4 (Poliovirus Receptor-Related 4 (PVRL4))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This PVRL4 antibody is un-conjugated

Application: Western Blotting (WB), ELISA

Product Details anti-PVRL4 Antibody

Binding Specificity: AA 312-361

Purpose: Nectin 4 Antibody

Specificity: Nectin 4 Polyclonal Antibody detects endogenous levels of Nectin 4 protein.

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Purity: > 95 %

Immunogen: The antiserum was produced against synthesized peptide derived from human PVRL4. AA range:312-361

Isotype: IgG

Application Details

Application Notes: WB 1:500 - 1:2000. ELISA: 1:5000. Not yet tested in other applications.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: Liquid in PBS containing 50 % glycerol, 0.5 % BSA and 0.02 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C/1 year

Expiry Date: 12 months

Target Details for PVRL4

Target: PVRL4 (Poliovirus Receptor-Related 4 (PVRL4))

Alternative Name: PVRL4

Background:

Synonyms: PVRL4, LNIR, PRR4, Poliovirus receptor-related protein 4, Ig superfamily receptor LNIR, Nectin-4

Background: This gene encodes a member of the nectin family. The encoded protein contains two immunoglobulin-like (Ig-like) C2-type domains and one Ig-like V-type domain. It is involved in cell adhesion through trans-homophilic and -heterophilic interactions. It is a single-pass type I membrane protein. The soluble form is produced by proteolytic cleavage at the cell surface by the metalloproteinase ADAM17/TACE. The secreted form is found in both breast tumor cell lines and breast tumor patients. Mutations in this gene are the cause of ectodermal dysplasia-syndactyly syndrome type 1, an autosomal recessive disorder. Alternatively spliced transcript variants have been found but the full-length nature of the variant has not been determined.[provided by RefSeq, Jan 2011],

Gene Name: PVRL4

Protein Name: Poliovirus receptor-related protein 4

Molecular Weight: 55 kDa

Gene ID: 81607

OMIM: 609607

UniProt: Q96NY8

Pathways: Cell-Cell Junction Organization