Serotonin Receptor 2B antibody (AA 15-64)

Catalog No. ABIN1535553

This Rabbit Polyclonal antibody specifically detects Serotonin Receptor 2B in WB, ELISA and IF. It exhibits reactivity toward Human.

Quick Overview for Serotonin Receptor 2B antibody (AA 15-64) (ABIN1535553)

Target: Serotonin Receptor 2B (HTR2B) (5-Hydroxytryptamine (serotonin) Receptor 2B (HTR2B))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Serotonin Receptor 2B antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunofluorescence (IF)

Product Details anti-Serotonin Receptor 2B Antibody

Binding Specificity: AA 15-64

Purpose: SR-2B Antibody

Specificity: SR-2B Polyclonal Antibody detects endogenous levels of SR-2B protein.

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Purity: > 95 %

Immunogen: The antiserum was produced against synthesized peptide derived from human HTR2B. AA range:15-64

Isotype: IgG

Application Details

Application Notes: WB 1:500 - 1:2000. IF 1:200 - 1:1000. ELISA: 1:10000. Not yet tested in other applications.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: Liquid in PBS containing 50 % glycerol, 0.5 % BSA and 0.02 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C/1 year

Expiry Date: 12 months

Target Details for Serotonin Receptor 2B

Target: Serotonin Receptor 2B (HTR2B) (5-Hydroxytryptamine (serotonin) Receptor 2B (HTR2B))

Alternative Name: HTR2B

Background:

Synonyms: HTR2B, 5-hydroxytryptamine receptor 2B, 5-HT-2B, 5-HT2B, Serotonin receptor 2B

Background: This gene encodes one of the several different receptors for 5-hydroxytryptamine (serotonin) that belongs to the G-protein coupled receptor 1 family. Serotonin is a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. Serotonin receptors mediate many of the central and peripheral physiologic functions of serotonin, including regulation of cardiovascular functions and impulsive behavior. Population and family-based analyses of a minor allele (glutamine-to-stop substitution, designated Q20*) which blocks expression of this protein, and knockout studies in mice, suggest a role for this gene in impulsivity. However, other factors, such as elevated testosterone levels, may also be involved. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Mar 2016],

Gene Name: HTR2B

Protein Name: 5-hydroxytryptamine receptor 2B

Molecular Weight: 54 kDa

Gene ID: 3357

OMIM: 601122

UniProt: P41595

Pathways: JAK-STAT Signaling, Inositol Metabolic Process, Regulation of G-Protein Coupled Receptor Protein Signaling, Regulation of Carbohydrate Metabolic Process