ADRA2A antibody (AA 281-330)

Catalog No. ABIN1535561

The Rabbit Polyclonal anti-ADRA2A antibody (ABIN1535561) specifically detects ADRA2A in WB, ELISA and IF. The antibody is reactive with Human, Rat and Mouse samples.

Quick Overview for ADRA2A antibody (AA 281-330) (ABIN1535561)

Target: ADRA2A (Alpha-2A Adrenergic Receptor (ADRA2A))

Reactivity: Human, Rat, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This ADRA2A antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunofluorescence (IF)

Product Details anti-ADRA2A Antibody

Binding Specificity: AA 281-330

Purpose: AR-α2A Antibody

Specificity: AR-α2A Polyclonal Antibody detects endogenous levels of AR-α2A protein.

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Purity: > 95 %

Immunogen: The antiserum was produced against synthesized peptide derived from human ADRA2A. AA range:281-330

Isotype: IgG

Application Details

Application Notes: WB 1:500 - 1:2000. IF 1:200 - 1:1000. ELISA: 1:20000. Not yet tested in other applications.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: Liquid in PBS containing 50 % glycerol, 0.5 % BSA and 0.02 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C/1 year

Expiry Date: 12 months

Target Details for ADRA2A

Target: ADRA2A (Alpha-2A Adrenergic Receptor (ADRA2A))

Alternative Name: ADRA2A

Background:

Synonyms: ADRA2A, ADRA2R, ADRAR, Alpha-2A adrenergic receptor, Alpha-2 adrenergic receptor subtype C10, Alpha-2A adrenoreceptor, Alpha-2A adrenoceptor, Alpha-2AAR

Background: Alpha-2-adrenergic receptors are members of the G protein-coupled receptor superfamily. They include 3 highly homologous subtypes: alpha2A, alpha2B, and alpha2C. These receptors have a critical role in regulating neurotransmitter release from sympathetic nerves and from adrenergic neurons in the central nervous system. Studies in mouse revealed that both the alpha2A and alpha2C subtypes were required for normal presynaptic control of transmitter release from sympathetic nerves in the heart and from central noradrenergic neurons, the alpha2A subtype inhibited transmitter release at high stimulation frequencies, whereas the alpha2C subtype modulated neurotransmission at lower levels of nerve activity.This gene encodes alpha2A subtype and it contains no introns in either its coding or untranslated sequences. [provided by RefSeq, Jul 2008],

Gene Name: ADRA2A

Protein Name: Alpha-2A adrenergic receptor

Molecular Weight: 48 kDa

Gene ID: 150

OMIM: 104210

UniProt: P08913

Pathways: EGFR Signaling Pathway, Negative Regulation of Hormone Secretion, Carbohydrate Homeostasis, cAMP Metabolic Process, Regulation of G-Protein Coupled Receptor Protein Signaling, Negative Regulation of Transporter Activity