MMP17 antibody (Cleaved-Gln129)

Catalog No. ABIN1536144

This Rabbit Polyclonal antibody specifically detects MMP17 in WB and ELISA. It exhibits reactivity toward Human, Mouse and Rat.

Quick Overview for MMP17 antibody (Cleaved-Gln129) (ABIN1536144)

Target: MMP17 (Matrix Metallopeptidase 17 (Membrane-inserted) (MMP17))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This MMP17 antibody is un-conjugated

Application: Western Blotting (WB), ELISA

Product Details anti-MMP17 Antibody

Binding Specificity: AA 110-159, Cleaved-Gln129

Purpose: Cleaved-MMP-17 (Q129) Antibody

Specificity: Cleaved-MMP-17 (Q129) Polyclonal Antibody detects endogenous levels of fragment of activated MMP-17 protein resulting from cleavage adjacent to Q129.

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Purity: > 95 %

Immunogen: The antiserum was produced against synthesized peptide derived from human MMP17. AA range:110-159

Isotype: IgG

Application Details

Application Notes: WB 1:500 - 1:2000. ELISA: 1:10000. Not yet tested in other applications.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: Liquid in PBS containing 50 % glycerol, 0.5 % BSA and 0.02 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C/1 year

Expiry Date: 12 months

Target Details for MMP17

Target: MMP17 (Matrix Metallopeptidase 17 (Membrane-inserted) (MMP17))

Alternative Name: MMP17

Background:

Synonyms: MMP17, MT4MMP, Matrix metalloproteinase-17, MMP-17, Membrane-type matrix metalloproteinase 4, MT-MMP 4, MTMMP4, Membrane-type-4 matrix metalloproteinase, MT4-MMP, MT4MMP

Background: This gene encodes a member of the peptidase M10 family and membrane-type subfamily of matrix metalloproteinases (MMPs). Proteins in this family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Members of this subfamily contain a transmembrane domain suggesting that these proteins are expressed at the cell surface rather than secreted. The encoded preproprotein is proteolytically processed to generate the mature protease. This protein is unique among the membrane-type matrix metalloproteinases in that it is anchored to the cell membrane via a glycosylphosphatidylinositol (GPI) anchor. Elevated expression of the encoded protein has been observed in osteoarthritis and multiple human cancers. [provided by RefSeq, Jan 2016],

Gene Name: MMP17

Protein Name: Matrix metalloproteinase-17

Molecular Weight: 53 kDa

Gene ID: 4326

OMIM: 602285

UniProt: Q9ULZ9