NOTCH2 antibody (Cleaved-Ala1734)

Catalog No. ABIN1536149

The Rabbit Polyclonal anti-NOTCH2 antibody (ABIN1536149) specifically detects NOTCH2 in WB and ELISA. The antibody is reactive with Human, Mouse and Rat samples.

Quick Overview for NOTCH2 antibody (Cleaved-Ala1734) (ABIN1536149)

Target: NOTCH2 (Notch 2 (NOTCH2))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This NOTCH2 antibody is un-conjugated

Application: Western Blotting (WB), ELISA

Product Details anti-NOTCH2 Antibody

Binding Specificity: AA 1715-1764, Cleaved-Ala1734

Purpose: Cleaved-Notch 2 (A1734) Antibody

Specificity: Cleaved-Notch 2 (A1734) Polyclonal Antibody detects endogenous levels of fragment of activated Notch 2 protein resulting from cleavage adjacent to A1734.

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Purity: > 95 %

Immunogen: The antiserum was produced against synthesized peptide derived from human NOTCH2. AA range:1715-1764

Isotype: IgG

Application Details

Application Notes: WB 1:500 - 1:2000. ELISA: 1:10000. Not yet tested in other applications.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: Liquid in PBS containing 50 % glycerol, 0.5 % BSA and 0.02 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C/1 year

Expiry Date: 12 months

Target Details for NOTCH2

Target: NOTCH2 (Notch 2 (NOTCH2))

Alternative Name: NOTCH2

Background:

Synonyms: NOTCH2, Neurogenic locus notch homolog protein 2, Notch 2, hN2

Background: notch 2(NOTCH2) Homo sapiens This gene encodes a member of the Notch family. Members of this Type 1 transmembrane protein family share structural characteristics including an extracellular domain consisting of multiple epidermal growth factor-like (EGF) repeats, and an intracellular domain consisting of multiple, different domain types. Notch family members play a role in a variety of developmental processes by controlling cell fate decisions. The Notch signaling network is an evolutionarily conserved intercellular signaling pathway which regulates interactions between physically adjacent cells. In Drosophilia, notch interaction with its cell-bound ligands (delta, serrate) establishes an intercellular signaling pathway that plays a key role in development. Homologues of the notch-ligands have also been identified in human, but precise interactions between these ligands and the human notch homologues remain to be determined. This protein is cle

Gene Name: NOTCH2

Protein Name: Neurogenic locus notch homolog protein 2

Molecular Weight: 79 kDa

Gene ID: 4853

OMIM: 600275

UniProt: Q04721

Pathways: Notch Signaling, Stem Cell Maintenance