STK4 antibody (C-Term)

Catalog No. ABIN1537341

The Rabbit Polyclonal anti-STK4 antibody (Clone RB37147) (ABIN1537341) specifically detects STK4 in WB. The antibody is reactive with Mouse samples.

Quick Overview for STK4 antibody (C-Term) (ABIN1537341)

Target: STK4 (serine/threonine Kinase 4 (STK4))

Reactivity: Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This STK4 antibody is un-conjugated

Application: Western Blotting (WB)

Clone: RB37147

Product Details anti-STK4 Antibody

Binding Specificity: AA 443-470, C-Term

Purification: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogen: This Mouse Stk4 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 443-470 amino acids from the C-terminal region of mouse Stk4.

Isotype: Ig Fraction

Application Details

Application Notes: WB: 1:1000

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Mouse Stk4 Antibody (C-term) can be refrigerated at 2-8 °C for up to 6 months. For long term storage, keep at -20 °C.

Expiry Date: 6 months

Target Details for STK4

Target: STK4 (serine/threonine Kinase 4 (STK4))

Alternative Name: Stk4

Background: Stress-activated, pro-apoptotic kinase which, following caspase-cleavage, enters the nucleus and induces chromatin condensation followed by internucleosomal DNA fragmentation. Key component of the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein MST1/MST2, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Phosphorylation of YAP1 by LATS2 inhibits its translocation into the nucleus to regulate cellular genes important for cell proliferation, cell death, and cell migration. MST1/MST2 are required to repress proliferation of mature hepatocytes, to prevent activation of facultative adult liver stem cells (oval cells), and to inhibit tumor formation. Phosphorylates 'Ser-14' of histone H2B (H2BS14ph) during apoptosis. Phosphorylates FOXO3 upon oxidative stress, which results in its nuclear translocation and cell death initiation.

Molecular Weight: 55541

Gene ID: 58231

NCBI Accession: NP_067395

UniProt: Q9JI11

Pathways: Tube Formation