SOCS7 antibody (C-Term)

Catalog No. ABIN1537362

This anti-SOCS7 antibody is a Rabbit Polyclonal antibody detecting SOCS7 in WB. Suitable for Human.

Quick Overview for SOCS7 antibody (C-Term) (ABIN1537362)

Target: SOCS7 (Suppressor of Cytokine Signaling 7 (SOCS7))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This SOCS7 antibody is un-conjugated

Application: Western Blotting (WB)

Clone: RB37084

Product Details anti-SOCS7 Antibody

Binding Specificity: AA 458-486, C-Term

Predicted Reactivity: M

Purification: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogen: This SOCS7 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 458-486 amino acids from the C-terminal region of human SOCS7.

Isotype: Ig Fraction

Application Details

Application Notes: WB: 1:1000

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: SOCS7 Antibody (C-term) can be refrigerated at 2-8 °C for up to 6 months. For long term storage, keep at -20 °C.

Expiry Date: 6 months

Target Details for SOCS7

Target: SOCS7 (Suppressor of Cytokine Signaling 7 (SOCS7))

Alternative Name: SOCS7

Background: Regulates signaling cascades probably through protein ubiquitination and/or sequestration. Functions in insulin signaling and glucose homeostasis through IRS1 ubiquitination and subsequent proteasomal degradation. Inhibits also prolactin, growth hormone and leptin signaling by preventing STAT3 and STAT5 activation, sequestering them in the cytoplasm and reducing their binding to DNA. May be a substrate recognition component of a SCF-like E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins (By similarity).

Molecular Weight: 62969

Gene ID: 30837

NCBI Accession: NP_055413

UniProt: O14512