SOCS7 antibody (AA 458-486)

Catalog No. ABIN3029049

The Rabbit Polyclonal anti-SOCS7 antibody (ABIN3029049) specifically detects SOCS7 in WB and ELISA. The antibody is reactive with Human samples.

Quick Overview for SOCS7 antibody (AA 458-486) (ABIN3029049)

Target: SOCS7 (Suppressor of Cytokine Signaling 7 (SOCS7))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This SOCS7 antibody is un-conjugated

Application: Western Blotting (WB), ELISA

Product Details anti-SOCS7 Antibody

Binding Specificity: AA 458-486

Purpose: SOCS7 Antibody

Cross-Reactivity (Details): Expected species reactivity: Mouse

Purification: Antigen affinity

Immunogen: A portion of amino acids 458-486 from the human protein was used as the immunogen for this SOCS7 antibody.

Isotype: Ig Fraction

Application Details

Application Notes: Titration of the SOCS7 antibody may be required due to differences in protocols and secondary/substrate sensitivity.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: In 1X PBS, pH 7.4, with 0.09 % sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Aliquot the SOCS7 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

Target Details for SOCS7

Target: SOCS7 (Suppressor of Cytokine Signaling 7 (SOCS7))

Alternative Name: SOCS7

Background: Regulates signaling cascades probably through protein ubiquitination and/or sequestration. Functions in insulin signaling and glucose homeostasis through IRS1 ubiquitination and subsequent proteasomal degradation. Inhibits also prolactin, growth hormone and leptin signaling by preventing STAT3 and STAT5 activation, sequestering them in the cytoplasm and reducing their binding to DNA. May be a substrate recognition component of a SCF-like E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins (By similarity).

UniProt: O14512