SOCS7 antibody (AA 458-486)

Catalog No. ABIN3029049

Product Details anti-SOCS7 Antibody

Target: SOCS7 (Suppressor of Cytokine Signaling 7 (SOCS7))

Binding Specificity: AA 458-486

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This SOCS7 antibody is un-conjugated

Application: ELISA, Western Blotting (WB)

Cross-Reactivity (Details): Expected species reactivity: Mouse

Purification: Antigen affinity purified

Immunogen: A portion of amino acids 458-486 from the human protein was used as the immunogen for this SOCS7 antibody.

Isotype: Ig Fraction

Application Details

Application Notes: Titration of the SOCS7 antibody may be required due to differences in protocols and secondary/substrate sensitivity.\. Western blot: 1:1000

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: In 1X PBS, pH 7.4, with 0.09 % sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Aliquot the SOCS7 antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.

Target Details for SOCS7

Target: SOCS7 (Suppressor of Cytokine Signaling 7 (SOCS7))

Alternative Name: SOCS7 (SOCS7 Products)

Synonyms: NAP4 antibody, NCKAP4 antibody, SOCS4 antibody, SOCS6 antibody, 2310063P06Rik antibody, C85125 antibody, Nap4 antibody, GB13951 antibody, zgc:175115 antibody, SOCS7 antibody, socs7 antibody, suppressor of cytokine signaling 7 antibody, suppressor of cytokine signaling antibody, SOCS7 antibody, Socs7 antibody, LOC413772 antibody, socs7 antibody

Background: Regulates signaling cascades probably through protein ubiquitination and/or sequestration. Functions in insulin signaling and glucose homeostasis through IRS1 ubiquitination and subsequent proteasomal degradation. Inhibits also prolactin, growth hormone and leptin signaling by preventing STAT3 and STAT5 activation, sequestering them in the cytoplasm and reducing their binding to DNA. May be a substrate recognition component of a SCF-like E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins (By similarity).

UniProt: O14512