PTEN antibody (pTyr174)

Catalog No. ABIN1539742

This Rabbit Polyclonal antibody specifically detects PTEN in DB. It exhibits reactivity toward Human.

Quick Overview for PTEN antibody (pTyr174) (ABIN1539742)

Target: PTEN (Phosphatase and Tensin Homolog (PTEN))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This PTEN antibody is un-conjugated

Application: Dot Blot (DB)

Clone: RB39745

Product Details anti-PTEN Antibody

Binding Specificity: pTyr174

Predicted Reactivity: M, X

Purification: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogen: This PTEN Antibody is generated from rabbits immunized with a KLH conjugated synthetic phosphopeptide corresponding to amino acid residues surrounding Y174 of human PTEN.

Isotype: Ig Fraction

Application Details

Application Notes: DB: 1:500

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Phospho-PTEN-Y174 Antibody can be refrigerated at 2-8 °C for up to 6 months. For long term storage, keep at -20 °C.

Expiry Date: 6 months

Target Details for PTEN

Target: PTEN (Phosphatase and Tensin Homolog (PTEN))

Alternative Name: PTEN

Background: This gene was identified as a tumor suppressor that is mutated in a large number of cancers at high frequency. The protein encoded this gene is a phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase. It contains a tensin like domain as well as a catalytic domain similar to that of the dual specificity protein tyrosine phosphatases. Unlike most of the protein tyrosine phosphatases, this protein preferentially dephosphorylates phosphoinositide substrates. It negatively regulates intracellular levels of phosphatidylinositol-3,4,5-trisphosphate in cells and functions as a tumor suppressor by negatively regulating AKT/PKB signaling pathway.

Molecular Weight: 47166

Gene ID: 5728

NCBI Accession: NP_000305

UniProt: P60484

Pathways: TCR Signaling, Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Inositol Metabolic Process, Synaptic Membrane, Regulation of Cell Size, Autophagy, Platelet-derived growth Factor Receptor Signaling, Signaling of Hepatocyte Growth Factor Receptor, BCR Signaling