GSTM1 antibody (AA 184-211)

Catalog No. ABIN1539938

The Mouse Monoclonal anti-GSTM1 antibody has been validated for WB. It is suitable to detect GSTM1 in samples from Human.

Quick Overview for GSTM1 antibody (AA 184-211) (ABIN1539938)

Target: GSTM1 (Glutathione S-Transferase mu 1 (GSTM1))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This GSTM1 antibody is un-conjugated

Application: Western Blotting (WB)

Clone: 524CT17-2-5

Product Details anti-GSTM1 Antibody

Binding Specificity: AA 184-211

Purification: Mouse monoclonal antibody supplied in crude ascites with 0.09% (W/V) sodium azide.

Immunogen: This GSTM1 antibody is generated from mice immunized with a KLH conjugated synthetic peptide between 184-211 amino acids from human GSTM1.

Isotype: IgM

Application Details

Application Notes: WB: 1:500~2000

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Mouse monoclonal antibody supplied in crude ascites with 0.09 % (W/V) sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: GSTM1 Antibody(Ascites) can be refrigerated at 2-8 °C for up to 6 months. For long term storage, keep at -20 °C.

Expiry Date: 6 months

Target Details for GSTM1

Target: GSTM1 (Glutathione S-Transferase mu 1 (GSTM1))

Alternative Name: GSTM1

Background: Cytosolic and membrane-bound forms of glutathione S-transferase are encoded by two distinct supergene families. At present, eight distinct classes of the soluble cytoplasmic mammalian glutathione S-transferases have been identified: alpha, kappa, mu, omega, pi, sigma, theta and zeta. This gene encodes a glutathione S-transferase that belongs to the mu class. The mu class of enzymes functions in the detoxification of electrophilic compounds, including carcinogens, therapeutic drugs, environmental toxins and products of oxidative stress, by conjugation with glutathione. The genes encoding the mu class of enzymes are organized in a gene cluster on chromosome 1p13.3 and are known to be highly polymorphic. These genetic variations can change an individual's susceptibility to carcinogens and toxins as well as affect the toxicity and efficacy of certain drugs. Null mutations of this class mu gene have been linked with an increase in a number of cancers, likely due to an increased susceptibility to environmental toxins and carcinogens. Multiple protein isoforms are encoded by transcript variants of this gene.

Molecular Weight: 25712

Gene ID: 2944

NCBI Accession: NP_000552, NP_666533

UniProt: P09488

Pathways: Negative Regulation of Transporter Activity