TIE1 antibody

Catalog No. ABIN1589940

The Rabbit Polyclonal anti-TIE1 antibody (ABIN1589940) specifically detects TIE1 in WB. The antibody is reactive with Mouse samples.

Quick Overview for TIE1 antibody (ABIN1589940)

Target: TIE1 (tyrosine Kinase with Immunoglobulin-Like and EGF-Like Domains 1 (TIE1))

Reactivity: Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This TIE1 antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-TIE1 Antibody

Purpose: TIE-1 antibody

Specificity: Recombinant mouse sTIE-1

Characteristics: Chromosomal location: 4 D2.1, 4 50.0 cM

Purification: Protein A purified

Immunogen: Recombinant mouse sTIE-1 (ABIN1589959)

Isotype: IgG

Application Details

Application Notes: Western Blot: use at 2-5 μg/mL.

Restrictions: For Research Use only

Handling

Format: Lyophilized

Reconstitution: Centrifuge vial prior to opening. Reconstitute in sterile water to a concentration of 0.1-1.0 mg/mL.

Buffer: PBS

Handling Advice: Centrifuge vial prior to opening.

Storage: 4 °C,-20 °C

Storage Comment: The lyophilized antibody is stable for at least 2 years at -20°C. After sterile reconstitution the antibody is stable at 2-8°C for up to 6 months. Frozen aliquots are stable for at least 6 months when stored at -20°C. Addition of a carrier protein or 50% glycerol is recommended for frozen aliquots.

Expiry Date: 24 months

Target Details for TIE1

Target: TIE1 (tyrosine Kinase with Immunoglobulin-Like and EGF-Like Domains 1 (TIE1))

Alternative Name: TIE-1

Background: Tie1, TIE, tie-1, D430008P04Rik,TIE-1 (tyrosine kinase with Ig and EGF homology domains 1) and TIE-2/Tek comprise a receptor tyrosine kinase (RTK) subfamily with unique structural characteristics: two immunoglobulin-like domains flanking three epidermal growth factor (EGF)-like domains and followed by three fibronectin type III-like repeats in the extracellular region and a split tyrosine kinase domain in the cytoplasmic region. These receptors are expressed primarily on endothelial and hematopoietic progenitor cells and play critical roles in angiogenesis, vasculogenesis and hematopoiesis.

Gene ID: 21846

NCBI Accession: NM_011587, NP_035717

UniProt: Q06806

Pathways: RTK Signaling